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Genes 2018, 9(4), 178; https://doi.org/10.3390/genes9040178

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

1
Molecular Oncology Laboratory, Victorian Infectious Diseases Reference Laboratory and the Doherty Institute, University of Melbourne, Melbourne, VIC 3000, Australia
2
Cancer and Cell Signalling Laboratory, European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff CF24 4HQ, Wales, UK
3
School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA 6102, Australia
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 19 February 2018 / Revised: 16 March 2018 / Accepted: 19 March 2018 / Published: 23 March 2018
(This article belongs to the Special Issue Wnt Signaling in Stem Cells)
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Abstract

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This review will describe the huge advances in our understanding of how stem cell functions in the gastrointestinal tract are regulated by Wnt signalling, including how deregulated Wnt signalling can hijack these functions to transform cells and lead to cancer. View Full-Text
Keywords: stem cells; Wnt signalling; epithelium; cancer; regeneration; plasticity; intestine; stomach; gastric stem cells; Wnt signalling; epithelium; cancer; regeneration; plasticity; intestine; stomach; gastric
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Flanagan, D.J.; Austin, C.R.; Vincan, E.; Phesse, T.J. Wnt Signalling in Gastrointestinal Epithelial Stem Cells. Genes 2018, 9, 178.

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