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Genes 2018, 9(2), 107; https://doi.org/10.3390/genes9020107

Alternative Splicing of Transcription Factors Genes in Muscle Physiology and Pathology

University of Modena and Reggio Emilia, Department of Life Sciences, Modena, Italy
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Received: 15 January 2018 / Revised: 10 February 2018 / Accepted: 13 February 2018 / Published: 19 February 2018
(This article belongs to the Special Issue Aberrant Pre-mRNA Splicing in Disease)
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Abstract

Skeletal muscle formation is a multi-step process that is governed by complex networks of transcription factors. The regulation of their functions is in turn multifaceted, including several mechanisms, among them alternative splicing (AS) plays a primary role. On the other hand, altered AS has a role in the pathogenesis of numerous muscular pathologies. Despite these premises, the causal role played by the altered splicing pattern of transcripts encoding myogenic transcription factors in neuromuscular diseases has been neglected so far. In this review, we systematically investigate what has been described about the AS patterns of transcription factors both in the physiology of the skeletal muscle formation process and in neuromuscular diseases, in the hope that this may be useful in re-evaluating the potential role of altered splicing of transcription factors in such diseases. View Full-Text
Keywords: skeletal muscle; alternative splicing; transcription factor; differentiation; myogenesis; neuromuscular disease skeletal muscle; alternative splicing; transcription factor; differentiation; myogenesis; neuromuscular disease
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Imbriano, C.; Molinari, S. Alternative Splicing of Transcription Factors Genes in Muscle Physiology and Pathology. Genes 2018, 9, 107.

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