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Genes 2018, 9(3), 161; https://doi.org/10.3390/genes9030161

Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets

Faculty of Health and Applied Sciences, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UK
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Received: 22 January 2018 / Revised: 5 March 2018 / Accepted: 6 March 2018 / Published: 13 March 2018
(This article belongs to the Special Issue Aberrant Pre-mRNA Splicing in Disease)
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Abstract

Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets. View Full-Text
Keywords: Hippo pathway; alternative splicing; yes-associated protein; splice-switching oligonucleotides; gene therapy Hippo pathway; alternative splicing; yes-associated protein; splice-switching oligonucleotides; gene therapy
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Porazinski, S.; Ladomery, M. Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets. Genes 2018, 9, 161.

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