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Genes 2018, 9(12), 596; https://doi.org/10.3390/genes9120596

N6-methyladenosine (m6A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review

Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, Poland
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Received: 25 October 2018 / Revised: 26 November 2018 / Accepted: 28 November 2018 / Published: 30 November 2018
(This article belongs to the Special Issue RNA Modifications)
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Abstract

N6-methyladenosine (m6A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m6A has peaked again. Similar to animal mRNAs, plant mRNAs are also m6A methylated, within a specific sequence motif which is conserved across these kingdoms. m6A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m6A. This review aims to put together the current knowledge regarding m6A in Arabidopsis thaliana. View Full-Text
Keywords: N6-methyladenosine; mRNA m6A methyltransferase (MTA), MTB; FIP37; ALKBH; YTDHF; Arabidopsis N6-methyladenosine; mRNA m6A methyltransferase (MTA), MTB; FIP37; ALKBH; YTDHF; Arabidopsis
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Bhat, S.S.; Bielewicz, D.; Jarmolowski, A.; Szweykowska-Kulinska, Z. N6-methyladenosine (m6A): Revisiting the Old with Focus on New, an Arabidopsis thaliana Centered Review. Genes 2018, 9, 596.

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