Next Article in Journal
Acknowledgement to Reviewers of Genes in 2017
Next Article in Special Issue
lncRNA Gene Signatures for Prediction of Breast Cancer Intrinsic Subtypes and Prognosis
Previous Article in Journal
Structural and Evolutionary Relationships in the Giant Sex Chromosomes of Three Microtus Species
Previous Article in Special Issue
MiRNA Influences in Neuroblast Modulation: An Introspective Analysis
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Genes 2018, 9(1), 29;

The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer

Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA
Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Author to whom correspondence should be addressed.
Received: 7 November 2017 / Revised: 21 December 2017 / Accepted: 4 January 2018 / Published: 10 January 2018
(This article belongs to the Special Issue Non-coding RNAs)
Full-Text   |   PDF [9501 KB, uploaded 10 January 2018]   |  


Triple-negative breast cancer (TNBC) is an operational term for breast cancers lacking targetable estrogen receptor expression and HER2 amplifications. TNBC is, therefore, inherently heterogeneous, and is associated with worse prognosis, greater rates of metastasis, and earlier onset. TNBC displays mutational and transcriptional diversity, and distinct mRNA transcriptional subtypes exhibiting unique biology. High-throughput sequencing has extended cancer research far beyond protein coding regions that include non-coding small RNAs, such as miRNA, isomiR, tRNA, snoRNAs, snRNA, yRNA, 7SL, and 7SK. In this study, we performed small RNA profiling of 26 TNBC cell lines, and compared the abundance of non-coding RNAs among the transcriptional subtypes of triple negative breast cancer. We also examined their co-expression pattern with corresponding mRNAs. This study provides a detailed description of small RNA expression in triple-negative breast cancer cell lines that can aid in the development of future biomarker and novel targeted therapies. View Full-Text
Keywords: small RNA; miRNA; TNBCtype; biomarker small RNA; miRNA; TNBCtype; biomarker

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Guo, Y.; Yu, H.; Wang, J.; Sheng, Q.; Zhao, S.; Zhao, Y.-Y.; Lehmann, B.D. The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer. Genes 2018, 9, 29.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top