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Genes 2018, 9(1), 26;

MiRNA Influences in Neuroblast Modulation: An Introspective Analysis

National Blood Transfusion Service, St. Luke’s Hospital, PTA1010 G’Mangia, Malta
School of Biomedical Science and Physiology, University of Wolverhampton, Wolverhampton WV1 1LY, UK
Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta
School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 22 December 2017 / Accepted: 29 December 2017 / Published: 9 January 2018
(This article belongs to the Special Issue Non-coding RNAs)
Full-Text   |   PDF [621 KB, uploaded 9 January 2018]   |  


Neuroblastoma (NB) is the most common occurring solid paediatric cancer in children under the age of five years. Whether of familial or sporadic origin, chromosome abnormalities contribute to the development of NB and cause dysregulation of microRNAs (miRNAs). MiRNAs are small non-coding, single stranded RNAs that target messenger RNAs at the post-transcriptional levels by repressing translation within all facets of human physiology. Such gene ‘silencing’ activities by miRNAs allows the development of regulatory feedback loops affecting multiple functions within the cell, including the possible differentiation of neural stem cell (NSC) lineage selection. Neurogenesis includes stages of self-renewal and fate specification of NSCs, migration and maturation of young neurones, and functional integration of new neurones into the neural circuitry, all of which are regulated by miRNAs. The role of miRNAs and their interaction in cellular processes are recognised aspects of cancer genetics, and miRNAs are currently employed as biomarkers for prognosis and tumour characterisation in multiple cancer models. Consequently, thorough understanding of the mechanisms of how these miRNAs interplay at the transcriptomic level will definitely lead to the development of novel, bespoke and efficient therapeutic measures, with this review focusing on the influences of miRNAs on neuroblast modulations leading to neuroblastoma. View Full-Text
Keywords: miRNA; neuroblast; nsc; neuroblastoma miRNA; neuroblast; nsc; neuroblastoma

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Zammit, V.; Baron, B.; Ayers, D. MiRNA Influences in Neuroblast Modulation: An Introspective Analysis. Genes 2018, 9, 26.

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