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Open AccessReview

NF-kappaB: Two Sides of the Same Coin

Laboratório de Célula-Tronco, Instituto Nacional de Câncer, 20230-130 Rio de Janeiro, RJ, Brazil
CAPES Foundation, Ministério da Educação, 70040-020 Brasília, DF, Brazil
Author to whom correspondence should be addressed.
These authors contributed equally to this article.
Genes 2018, 9(1), 24;
Received: 6 December 2017 / Revised: 2 January 2018 / Accepted: 5 January 2018 / Published: 9 January 2018
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies. In addition to the direct effects of NF-κB in cancer cells, it might also impact immune cells that can both promote or prevent tumor development. Currently, with the rise of cancer immunotherapy, the link among immune cells, inflammation, and cancer is a major focus, and NF-κB could be an important regulator for the success of these therapies. This review discusses the contrasting roles of NF-κB as a regulator of pro- and antitumor processes and its potential as a therapeutic target. View Full-Text
Keywords: NF-kB; NF-kappaB; signaling; cancer; inflammation; immune response; treatment; therapy NF-kB; NF-kappaB; signaling; cancer; inflammation; immune response; treatment; therapy
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Pires, B.R.B.; Silva, R.C.M.C.; Ferreira, G.M.; Abdelhay, E. NF-kappaB: Two Sides of the Same Coin. Genes 2018, 9, 24.

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