Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes
AbstractObjective: The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods. Results: We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44–2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54–0.81; p < 0.001). Conclusion: The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population. View Full-Text
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Li, Z.-P.; Zhang, M.; Gao, J.; Zhou, G.-Y.; Li, S.-Q.; An, Z.-M. Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes. Genes 2015, 6, 512-519.
Li Z-P, Zhang M, Gao J, Zhou G-Y, Li S-Q, An Z-M. Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes. Genes. 2015; 6(3):512-519.Chicago/Turabian Style
Li, Zhi-Peng; Zhang, Mei; Gao, Jie; Zhou, Guo-Yan; Li, Shuang-Qing; An, Zhen-Mei. 2015. "Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes." Genes 6, no. 3: 512-519.