CiteULike
Facebook
Mendeley
Twitter
Open AccessThis article is
Download PDF Full-Text [2237 KB, Updated Version, uploaded 20 August 2013 08:25 CEST]
- freely available
- re-usable
Genes 2013, 4(3), 388-434; doi:10.3390/genes4030388
Review
Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 7 May 2013; in revised form: 30 July 2013 / Accepted: 2 August 2013 / Published: 19 August 2013
(This article belongs to the Special Issue DNA Replication)
Download PDF Full-Text [2237 KB, Updated Version, uploaded 20 August 2013 08:25 CEST]
The original version is still available [2237 KB, uploaded 19 August 2013 10:26 CEST]
Abstract: Checkpoints monitor critical cell cycle events such as chromosome duplication and segregation. They are highly conserved mechanisms that prevent progression into the next phase of the cell cycle when cells are unable to accomplish the previous event properly. During S phase, cells also provide a surveillance mechanism called the DNA replication checkpoint, which consists of a conserved kinase cascade that is provoked by insults that block or slow down replication forks. The DNA replication checkpoint is crucial for maintaining genome stability, because replication forks become vulnerable to collapse when they encounter obstacles such as nucleotide adducts, nicks, RNA-DNA hybrids, or stable protein-DNA complexes. These can be exogenously induced or can arise from endogenous cellular activity. Here, we summarize the initiation and transduction of the replication checkpoint as well as its targets, which coordinate cell cycle events and DNA replication fork stability.
Keywords: checkpoint; replication; Mec1/ATR; Tel1/ATM; kinases
Article Statistics
Citations to this Article
Cite This Article
MDPI and ACS Style
Hustedt, N.; Gasser, S.M.; Shimada, K. Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase. Genes 2013, 4, 388-434.
AMA StyleHustedt N, Gasser SM, Shimada K. Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase. Genes. 2013; 4(3):388-434.
Chicago/Turabian StyleHustedt, Nicole; Gasser, Susan M.; Shimada, Kenji. 2013. "Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase." Genes 4, no. 3: 388-434.