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Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Author to whom correspondence should be addressed.
Genes 2013, 4(3), 388-434;
Received: 7 May 2013 / Revised: 30 July 2013 / Accepted: 2 August 2013 / Published: 19 August 2013
(This article belongs to the Special Issue DNA Replication)
PDF [2237 KB, uploaded 20 August 2013]


Checkpoints monitor critical cell cycle events such as chromosome duplication and segregation. They are highly conserved mechanisms that prevent progression into the next phase of the cell cycle when cells are unable to accomplish the previous event properly. During S phase, cells also provide a surveillance mechanism called the DNA replication checkpoint, which consists of a conserved kinase cascade that is provoked by insults that block or slow down replication forks. The DNA replication checkpoint is crucial for maintaining genome stability, because replication forks become vulnerable to collapse when they encounter obstacles such as nucleotide adducts, nicks, RNA-DNA hybrids, or stable protein-DNA complexes. These can be exogenously induced or can arise from endogenous cellular activity. Here, we summarize the initiation and transduction of the replication checkpoint as well as its targets, which coordinate cell cycle events and DNA replication fork stability. View Full-Text
Keywords: checkpoint; replication; Mec1/ATR; Tel1/ATM; kinases checkpoint; replication; Mec1/ATR; Tel1/ATM; kinases
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hustedt, N.; Gasser, S.M.; Shimada, K. Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase. Genes 2013, 4, 388-434.

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