Genes 2013, 4(3), 435-456; doi:10.3390/genes4030435
Review

siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries

1 Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA 2 Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
* Author to whom correspondence should be addressed.
Received: 15 May 2013; in revised form: 17 August 2013 / Accepted: 22 August 2013 / Published: 5 September 2013
(This article belongs to the Special Issue Gene Silencing)
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Abstract: Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery.
Keywords: brain; siRNA; RNAi; traumatic brain injury; stroke; ischemia; subarachnoid hemorrhage

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MDPI and ACS Style

Fukuda, A.M.; Badaut, J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes 2013, 4, 435-456.

AMA Style

Fukuda AM, Badaut J. siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries. Genes. 2013; 4(3):435-456.

Chicago/Turabian Style

Fukuda, Andrew M.; Badaut, Jerome. 2013. "siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries." Genes 4, no. 3: 435-456.

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