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Volume 16
Issue 5
10.3390/genes16050566
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Review

Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders

by
Olaia Martínez-Iglesias
*,
Vinogran Naidoo
,
Iván Carrera
,
Lola Corzo
and
Ramón Cacabelos
EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, Spain
*
Author to whom correspondence should be addressed.
Genes 2025, 16(5), 566; https://doi.org/10.3390/genes16050566 (registering DOI)
Submission received: 8 April 2025 / Revised: 6 May 2025 / Accepted: 7 May 2025 / Published: 10 May 2025
(This article belongs to the Section Epigenomics)
Versions Notes

Abstract

Cardiovascular disorders (CVDs) are the leading cause of mortality worldwide, highlighting an urgent need for innovative therapeutic strategies. Recent advancements highlight the potential of naturally derived bioproducts with epigenetic properties to offer protection against CVDs. These compounds act on key epigenetic mechanisms, DNA methylation, histone modifications, and non-coding RNA regulation to modulate gene expression essential for cardiovascular health. This review explores the effects of various bioproducts, such as polyphenols, flavonoids, and other natural extracts, on these epigenetic modifications and their potential benefits in preventing and managing CVDs. We discuss recent discoveries and clinical applications, providing insights into the epigenetic regulatory mechanisms of these compounds as potential epidrugs, naturally derived agents with promising therapeutic prospects in epigenetic therapy for CVDs.
Keywords: cardiovascular disorders; epigenetic; bioproduct; epidrug cardiovascular disorders; epigenetic; bioproduct; epidrug

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MDPI and ACS Style

Martínez-Iglesias, O.; Naidoo, V.; Carrera, I.; Corzo, L.; Cacabelos, R. Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders. Genes 2025, 16, 566. https://doi.org/10.3390/genes16050566

AMA Style

Martínez-Iglesias O, Naidoo V, Carrera I, Corzo L, Cacabelos R. Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders. Genes. 2025; 16(5):566. https://doi.org/10.3390/genes16050566

Chicago/Turabian Style

Martínez-Iglesias, Olaia, Vinogran Naidoo, Iván Carrera, Lola Corzo, and Ramón Cacabelos. 2025. "Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders" Genes 16, no. 5: 566. https://doi.org/10.3390/genes16050566

APA Style

Martínez-Iglesias, O., Naidoo, V., Carrera, I., Corzo, L., & Cacabelos, R. (2025). Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders. Genes, 16(5), 566. https://doi.org/10.3390/genes16050566

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