Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis
Abstract
1. Introduction
2. Materials and Methods
Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mean Difference | 95% CI | p-Value | |||
b2a2 | |||||
b3a2 | America | America | 14.85 | −5.472–35.17 | 0.1752 |
America | Europe | −16.19–45.89 | 0.5501 | ||
America | Asia | −16.19–45.90 | 0.5499 | ||
America | Africa | −16.19–45.89 | 0.5501 | ||
Europe | Europe | −5.472–35.17 | 0.1752 | ||
Europe | Asia | −16.19–45.90 | 0.5499 | ||
Europe | Africa | −16.19–45.89 | 0.5501 | ||
Asia | Asia | −5.472–35.17 | 0.1752 | ||
Asia | Africa | −16.20–45.89 | 0.5504 | ||
Africa | Africa | −5.472–35.17 | 0.1752 | ||
Mean difference | 95% CI | p-value | |||
e1a2 | |||||
b2a2 | America | America | 41.96 | 21.64–62.28 | 0.0012 * |
America | Europe | 10.92–73.00 | 0.0118 * | ||
America | Asia | 41.97 | 10.92–73.01 | ||
America | Africa | 41.96 | 10.92–73.00 | ||
Europe | Europe | 21.64–62.28 | 0.0012 * | ||
Europe | Asia | 41.97 | 10.92–73.01 | 0.0118 * | |
Europe | Africa | 41.96 | 10.92–73.00 | ||
Asia | Asia | 21.64–62.28 | 0.0012 * | ||
Asia | Africa | 10.92–73.00 | 0.0118 * | ||
Africa | Africa | 21.64–62.28 | 0.0012 * | ||
Mean difference | 95% CI | p-value | |||
e1a2 | |||||
b3a2 | America | America | 56.81 | 36.49–77.13 | 0.0002 * |
America | Europe | 25.77–87.85 | 0.0024 * | ||
America | Asia | 56.82 | 25.77–87.86 | ||
America | Africa | 56.81 | 25.77–87.85 | ||
Europe | Europe | 36.49–77.13 | 0.0002 * | ||
Europe | Asia | 56.82 | 25.77–87.86 | 0.0024 * | |
Europe | Africa | 56.81 | 25.77–87.85 | ||
Asia | Asia | 36.49–77.13 | 0.0002 * | ||
Asia | Africa | 25.77–87.85 | 0.0024 * | ||
Africa | Africa | 36.49–77.13 | 0.0002 * |
n | b3a2 % (n) | b2a2 % (n) | e1a2 % (n) | |
Mexico | 646 | 47.21 (305) | 50.15 (324) | 2.63 (17) |
USA | 396 | 49.49 (196) | 50.51 (200) | 0.00 (0) |
Pakistan | 135 | 62.96 (85) | 35.56 (48) | 1.48 (2) |
Brazil | 259 | 66.41 (172) | 33.59 (87) | 0.00 (0) |
Iran | 142 | 70.42 (100) | 28.17 (40) | 1.41 (2) |
Syria | 15 | 20.00 (3) | 80.00 (12) | 0.00 (0) |
Korea | 652 | 66.87 (436) | 33.13 (216) | 0.00 (0) |
Malaysia | 76 | 76.32 (58) | 21.05 (16) | 2.63 (2) |
Indonesia | 177 | 76.84 (136) | 23.16 (41) | 0.00 (0) |
India | 1395 | 63.94 (892) | 34.41 (480) | 1.65 (23) |
Canada | 144 | 57.64 (83) | 42.36 (61) | 0.00 (0) |
England | 71 | 54.93 (39) | 45.07 (32) | 0.00 (0) |
Germany | 1058 | 52.08 (551) | 47.92 (507) | 0.00 (0) |
Italy | 222 | 57.21 (127) | 42.79 (95) | 0.00 (0) |
Iraq | 98 | 60.20 (59) | 39.80 (39) | 0.00 (0) |
France | 32 | 59.38 (19) | 40.63 (13) | 0.00 (0) |
Sudan | 43 | 41.86 (18) | 58.14 (25) | 0.00 (0) |
Tunisia | 44 | 63.64 (28) | 36.36 (16) | 0.00 (0) |
Saudi Arabia | 128 | 64.06 (82) | 35.94 (46) | 0.00 (0) |
Poland | 62 | 70.97 (44) | 29.03 (18) | 0.00 (0) |
N | 5795 | 59.24 (3433) | 39.97 (2316) | 0.79 (46) |
n | b3a2 % (n) | b2a2 % (n) | e1a2 % (n) | |
Mexico | 646 | 47.2 (305) | 50.2 (324) | 2.6 (17) |
Cuba | 271 | 56.5 (153) | 41.0 (111) | 2.6 (7) |
Venezuela | 81 | 55.6 (45) | 44.4 (36) | 0.0 (0) |
Brazil | 21 | 57.1 (12) | 42.9 (9) | 0.0 (0) |
Bolivia | 250 | 61.6 (154) | 38.4 (96) | 0.0 (0) |
Chile | 19 | 73.7 (14) | 0.0 (0) | 26.3 (5) |
Guatemala | 34 | 44.1 (15) | 44.1 (15) | 11.8 (4) |
Colombia | 27 | 37.0 (10) | 59.3 (16) | 3.7 (1) |
Ecuador | 37 | 5.4 (2) | 94.6 (35) | 0.0 (0) |
N | 1386 | 51.2 (710) | 46.3 (642) | 2.5 (34) |
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Romero-Morelos, P.; González-Yebra, A.L.; Muñoz-López, D.; Lara-Lona, E.; González-Yebra, B. Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis. Genes 2024, 15, 232. https://doi.org/10.3390/genes15020232
Romero-Morelos P, González-Yebra AL, Muñoz-López D, Lara-Lona E, González-Yebra B. Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis. Genes. 2024; 15(2):232. https://doi.org/10.3390/genes15020232
Chicago/Turabian StyleRomero-Morelos, Pablo, Ana Lilia González-Yebra, Daniela Muñoz-López, Elia Lara-Lona, and Beatriz González-Yebra. 2024. "Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis" Genes 15, no. 2: 232. https://doi.org/10.3390/genes15020232
APA StyleRomero-Morelos, P., González-Yebra, A. L., Muñoz-López, D., Lara-Lona, E., & González-Yebra, B. (2024). Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis. Genes, 15(2), 232. https://doi.org/10.3390/genes15020232