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Volume 14
Issue 2
10.3390/genes14020356
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Article

Study on the Association between LRRC8B Gene InDel and Sheep Body Conformation Traits

by
Jiaqiang Zhang
1,†,
Zhansaya Toremurat
1,†,
Yilin Liang
1,
Jie Cheng
1,
Zhenzhen Sun
1,
Yangming Huang
1,
Junxia Liu
2,
BUREN Chaogetu
3,
Gang Ren
1,* and
Hong Chen
1,4,*
1
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China
2
College of Life Sciences, Northwest A&F University, Xianyang 712100, China
3
Animal Disease Control Center of Haixi Mongolian and Tibetan Autonomous Prefecture, Delingha 817000, China
4
College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Genes 2023, 14(2), 356; https://doi.org/10.3390/genes14020356
Submission received: 25 October 2022 / Revised: 23 December 2022 / Accepted: 16 January 2023 / Published: 30 January 2023
(This article belongs to the Special Issue Statistical Approaches for the Analysis of Genomic Data)
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Abstract

Marker-assisted selection is an important method for livestock breeding. In recent years, this technology has been gradually applied to livestock breeding to improve the body conformation traits. In this study, the LRRC8B (Leucine Rich Repeat Containing 8 VRAC Subunit B) gene was selected to evaluate the association between its genetic variations and the body conformation traits in two native sheep breeds in China. Four body conformation traits, including withers height, body length, chest circumference, and body weight, were collected from 269 Chaka sheep. We also collected the body length, chest width, withers height, chest depth, chest circumference, cannon bone circumference, and height at hip cross of 149 Small-Tailed Han sheep. Two different genotypes, ID and DD, were detected in all sheep. Our data showed that the polymorphism of the LRRC8B gene was significantly associated with chest depth (p < 0.05) in Small-Tailed Han sheep, and it is greater in sheep with DD than those with ID. In conclusion, our data suggested that the LRRC8B gene could serve as a candidate gene for marker-assisted selection in Small-Tailed Han sheep.
Keywords: LRRC8B gene; InDel; body conformation traits; sheep LRRC8B gene; InDel; body conformation traits; sheep
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MDPI and ACS Style

Zhang, J.; Toremurat, Z.; Liang, Y.; Cheng, J.; Sun, Z.; Huang, Y.; Liu, J.; Chaogetu, B.; Ren, G.; Chen, H. Study on the Association between LRRC8B Gene InDel and Sheep Body Conformation Traits. Genes 2023, 14, 356. https://doi.org/10.3390/genes14020356

AMA Style

Zhang J, Toremurat Z, Liang Y, Cheng J, Sun Z, Huang Y, Liu J, Chaogetu B, Ren G, Chen H. Study on the Association between LRRC8B Gene InDel and Sheep Body Conformation Traits. Genes. 2023; 14(2):356. https://doi.org/10.3390/genes14020356

Chicago/Turabian Style

Zhang, Jiaqiang, Zhansaya Toremurat, Yilin Liang, Jie Cheng, Zhenzhen Sun, Yangming Huang, Junxia Liu, BUREN Chaogetu, Gang Ren, and Hong Chen. 2023. "Study on the Association between LRRC8B Gene InDel and Sheep Body Conformation Traits" Genes 14, no. 2: 356. https://doi.org/10.3390/genes14020356

APA Style

Zhang, J., Toremurat, Z., Liang, Y., Cheng, J., Sun, Z., Huang, Y., Liu, J., Chaogetu, B., Ren, G., & Chen, H. (2023). Study on the Association between LRRC8B Gene InDel and Sheep Body Conformation Traits. Genes, 14(2), 356. https://doi.org/10.3390/genes14020356

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