Mitochondrial Control Region Variants Related to Breast Cancer
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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mtDNA Region (Positions) | Polymorphism | NCBI dbSNP ID | Breast Cancer, % | Controls, % | X2 |
---|---|---|---|---|---|
m.310del | rs869289246 | 34.6 (27/78) | 61.7 (21/34) | 0.007 * | |
HRV-II | m.310T>C | rs1556422421 | 5.1 (4/78) | 0 (0/34) | 0.178 |
(57–372) | m.310delinsCCTC | rS46492218 | 1.2 (1/78) | 2.9 (1/34) | 0.542 |
m.315dup | rs369786048 | 60.2 (47/78) | 38.2 (13/34) | 0.030 * | |
MT-ND3 (10059–10404) | m.10398A>G | rs2853826 | 18.0 (9/50) | 29.4 (10/34) | 0.219 |
HRV-I | m.16183A>C | rs28671493 | 12.8 (10/78) | 14.7 (5/34) | 0.787 |
(16024–16383) | m.16189T>C | rs28693675 | 18.8 (17/90) | 26.5 (9/34) | 0.354 |
m.16311T>C | rs34799580 | 12.2 (11/90) | 23.5 (8/34) | 0.118 | |
m.16519T>C | rs3937033 | 51.5 (34/66) | 58.8 (20/34) | 0.007 * |
mtDNA Region Genes (Positions) | Polymorphism | NCBI dbSNP ID | Breast Cancer, % | Controls, % | X2 |
---|---|---|---|---|---|
MT-RNR1 | |||||
MOTS (1343–1393) | m.1346A>G | rs879104061 | 1.9 (1/52) | 0 (0/34) | 0.416 |
MT-RNR2 | |||||
Humanin (2633–2707) | m.2706A>G | rs2854128 | 61.5 (32/52) | 76.4 (26/34) | 0.418 |
SHLP1 (10059–10404) | - | - | - | - | - |
SHLP2 (2088–2168) | m.2124A>G | - | 1.9 (1/52) | 0 (0/34) | 0.416 |
m.2145del | - | 1.9 (1/52) | 0 (0/34) | 0.416 | |
SHLP3 (1703–1819) | m.1709A>G | rs200251800 | 3.8 (2/52) | 11.8 (4/34) | 0.158 |
m.1716A>G | rs1556422559 | 1.9 (1/52) | 5.9 (2/34) | 0.327 | |
m.1719A>G | rs3928305 | 13.4 (7/52) | 5.9 (2/34) | 0.261 | |
m.1736A>G | rs193303006 | 3.8 (2/52) | 11.8 (4/34) | 0.158 | |
m.1811A>G | rs28358576 | 1.9 (1/52) | 2.9 (1/34) | 0.759 | |
SHLP4 (2442–2522) | m.2445A>G | - | 1.9 (1/52) | 0 (0/34) | 0.416 |
SHLP5 (2780–2854) | - | - | - | - | - |
SHLP6 (2990–3052) | m.3010A>G | rs3928306 | 21.1 (11/52) | 17.6 (6/34) | 0.689 |
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Vega Avalos, J.H.; Hernández, L.E.; Zuñiga, L.Y.; Sánchez-Parada, M.G.; González Santiago, A.E.; Román Pintos, L.M.; Castañeda Arellano, R.; Hernández-Ortega, L.D.; Mercado-Sesma, A.R.; Orozco-Luna, F.d.J.; et al. Mitochondrial Control Region Variants Related to Breast Cancer. Genes 2022, 13, 1962. https://doi.org/10.3390/genes13111962
Vega Avalos JH, Hernández LE, Zuñiga LY, Sánchez-Parada MG, González Santiago AE, Román Pintos LM, Castañeda Arellano R, Hernández-Ortega LD, Mercado-Sesma AR, Orozco-Luna FdJ, et al. Mitochondrial Control Region Variants Related to Breast Cancer. Genes. 2022; 13(11):1962. https://doi.org/10.3390/genes13111962
Chicago/Turabian StyleVega Avalos, Jorge Hermilo, Luis Enrique Hernández, Laura Yareni Zuñiga, María Guadalupe Sánchez-Parada, Ana Elizabeth González Santiago, Luis Miguel Román Pintos, Rolando Castañeda Arellano, Luis Daniel Hernández-Ortega, Arieh Roldán Mercado-Sesma, Felipe de Jesús Orozco-Luna, and et al. 2022. "Mitochondrial Control Region Variants Related to Breast Cancer" Genes 13, no. 11: 1962. https://doi.org/10.3390/genes13111962