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Article

Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer

1
Department of Molecular Medicine and Anatomy, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, Japan
2
Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, Japan
3
Department of Breast Surgical Oncology, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Keun Hur
Genes 2021, 12(2), 182; https://doi.org/10.3390/genes12020182
Received: 1 December 2020 / Revised: 17 January 2021 / Accepted: 21 January 2021 / Published: 27 January 2021
(This article belongs to the Special Issue Non-coding RNAs: Variety of Roles and Applications in Human Diseases)
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression, which play fundamental roles in cancer development. In this study, we found that homeobox A11 antisense RNA (HOXA11-AS), a highly expressed lncRNA in cell lines derived from prostate cancer bone metastases, promoted the cell invasion and proliferation of PC3 prostate cancer cells. Transcription factor homeobox B13 (HOXB13) was identified as an upstream regulator of HOXA11-AS.HOXA11-AS regulated bone metastasis-associated C-C motif chemokine ligand 2 (CCL2)/C-C chemokine receptor type 2 (CCR2) signaling in both PC3 prostate cancer cells and SaOS2 osteoblastic cells. The HOXB13/HOXA11-AS axis also regulated integrin subunits (ITGAV and ITGB1) specific to prostate cancer bone metastasis. HOXB13, in combination with HOXA11-AS, directly regulated the integrin-binding sialoprotein (IBSP) promoter. Furthermore, conditioned medium containing HOXA11-AS secreted from PC3 cells could induce the expression of CCL2 and IBSP in SaOS2 osteoblastic cells. These results suggest that prostate cancer HOXA11-AS and HOXB13 promote metastasis by regulation of CCL2/CCR2 cytokine and integrin signaling in autocrine and paracrine manners. View Full-Text
Keywords: HOXA11-AS; HOXB13; long noncoding RNA; metastasis; prostate cancer HOXA11-AS; HOXB13; long noncoding RNA; metastasis; prostate cancer
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MDPI and ACS Style

Misawa, A.; Kondo, Y.; Takei, H.; Takizawa, T. Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer. Genes 2021, 12, 182. https://doi.org/10.3390/genes12020182

AMA Style

Misawa A, Kondo Y, Takei H, Takizawa T. Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer. Genes. 2021; 12(2):182. https://doi.org/10.3390/genes12020182

Chicago/Turabian Style

Misawa, Aya, Yukihiro Kondo, Hiroyuki Takei, and Toshihiro Takizawa. 2021. "Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer" Genes 12, no. 2: 182. https://doi.org/10.3390/genes12020182

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