Next Article in Journal
MNBDR: A Module Network Based Method for Drug Repositioning
Previous Article in Journal
Genome-Wide Identification and Expression Profiling of the PDI Gene Family Reveals Their Probable Involvement in Abiotic Stress Tolerance in Tomato (Solanum lycopersicum L.)
Open AccessArticle

A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit

1
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
2
Joint International Research Laboratory of Agriculture & Agri-Product Safety, Yangzhou University, Yangzhou 225009, China
*
Author to whom correspondence should be addressed.
Genes 2021, 12(1), 24; https://doi.org/10.3390/genes12010024
Received: 26 October 2020 / Revised: 13 December 2020 / Accepted: 23 December 2020 / Published: 26 December 2020
(This article belongs to the Section Animal Genetics and Genomics)
The hair follicle (HF) growth cycle is a complex, multistep biological process, for which dysfunction affects hair-related diseases in humans and wool production in animals. In this study, a treatment combination of 10 ng/mL insulin-like growth factor-1 (IGF-1) and 20 ng/mL epidermal growth factor (EGF) significantly increased the elongation length of hair shafts for cultured HFs. The combined treatment of IGF-1 and EGF enhanced the proliferation of HFs and promoted HF growth and development in vitro. In vivo, the combined treatment of IGF-1 and EGF was subcutaneously injected into the dorsal skin in HF synchronized rabbits. The IGF-1 and EGF combination promoted the transition of the hair cycle from telogen to anagen and stimulated the growth of hair shafts. This IGF-1 and EGF combination maintained the structure of the HF and enhanced the cell proliferation of outer root sheaths and the dermal papilla within rabbit skin. The combined treatment of IGF-1 and EGF regulated HF-related genes, including LEF1, CCND1 and WNT2, suggesting that IGF-1 and EGF play a positive role in HF growth and development. Utilization of the combined IGF-1 and EGF treatment may assist with hair and wool production and HF related diseases in mammals. View Full-Text
Keywords: hair follicle; IGF-1; EGF; gene regulation hair follicle; IGF-1; EGF; gene regulation
Show Figures

Figure 1

MDPI and ACS Style

Zhao, B.; Li, J.; Chen, Q.; Yang, N.; Bao, Z.; Hu, S.; Chen, Y.; Wu, X. A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit. Genes 2021, 12, 24. https://doi.org/10.3390/genes12010024

AMA Style

Zhao B, Li J, Chen Q, Yang N, Bao Z, Hu S, Chen Y, Wu X. A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit. Genes. 2021; 12(1):24. https://doi.org/10.3390/genes12010024

Chicago/Turabian Style

Zhao, Bohao; Li, Jiali; Chen, Qiuran; Yang, Naisu; Bao, Zhiyuan; Hu, Shuaishuai; Chen, Yang; Wu, Xinsheng. 2021. "A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit" Genes 12, no. 1: 24. https://doi.org/10.3390/genes12010024

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop