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Extracellular Vesicles Derived from Human Gingival Mesenchymal Stem Cells: A Transcriptomic Analysis
Open AccessArticle

Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells

1
National Laboratory of Molecular Biology and Stem Cell Bioengineering of the National Institute of Biostructures and Biosystems (NIBB)—Eldor Lab, at the Innovation Accelerator, CNR, Via Piero Gobetti 101, 40129 Bologna, Italy
2
Department for Life Quality Studies (QuVi), University of Bologna, Corso D’Augusto 237, 47921 Rimini, Italy
3
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2020, 11(8), 909; https://doi.org/10.3390/genes11080909
Received: 1 July 2020 / Revised: 24 July 2020 / Accepted: 6 August 2020 / Published: 8 August 2020
(This article belongs to the Special Issue Stem Cells Application in Clinical Practice: Advances and Challenges)
In humans, sexual dimorphism can manifest in many ways and it is widely studied in several knowledge fields. It is increasing the evidence that also cells differ according to sex, a correlation still little studied and poorly considered when cells are used in scientific research. Specifically, our interest is on the sex-related dimorphism on the human mesenchymal stem cells (hMSCs) transcriptome. A systematic meta-analysis of hMSC microarrays was performed by using the Transcriptome Mapper (TRAM) software. This bioinformatic tool was used to integrate and normalize datasets from multiple sources and allowed us to highlight chromosomal segments and genes differently expressed in hMSCs derived from adipose tissue (hADSCs) of male and female donors. Chromosomal segments and differentially expressed genes in male and female hADSCs resulted to be related to several processes as inflammation, adipogenic and neurogenic differentiation and cell communication. Obtained results lead us to hypothesize that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes. We believe that it should be considered in biologic research and stem cell therapy. View Full-Text
Keywords: sex; sex dimorphism; mesenchymal stem cells; human adipose derived stem cells; microarray; gene expression sex; sex dimorphism; mesenchymal stem cells; human adipose derived stem cells; microarray; gene expression
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MDPI and ACS Style

Bianconi, E.; Casadei, R.; Frabetti, F.; Ventura, C.; Facchin, F.; Canaider, S. Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells. Genes 2020, 11, 909. https://doi.org/10.3390/genes11080909

AMA Style

Bianconi E, Casadei R, Frabetti F, Ventura C, Facchin F, Canaider S. Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells. Genes. 2020; 11(8):909. https://doi.org/10.3390/genes11080909

Chicago/Turabian Style

Bianconi, Eva; Casadei, Raffaella; Frabetti, Flavia; Ventura, Carlo; Facchin, Federica; Canaider, Silvia. 2020. "Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells" Genes 11, no. 8: 909. https://doi.org/10.3390/genes11080909

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