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Open AccessArticle

Evolution of the Human Chromosome 13 Synteny: Evolutionary Rearrangements, Plasticity, Human Disease Genes and Cancer Breakpoints

1
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90100 Palermo, Italy
2
Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Genes 2020, 11(4), 383; https://doi.org/10.3390/genes11040383
Received: 10 February 2020 / Revised: 27 March 2020 / Accepted: 27 March 2020 / Published: 1 April 2020
(This article belongs to the Special Issue A Tale of Genes and Genomes)
The history of each human chromosome can be studied through comparative cytogenetic approaches in mammals which permit the identification of human chromosomal homologies and rearrangements between species. Comparative banding, chromosome painting, Bacterial Artificial Chromosome (BAC) mapping and genome data permit researchers to formulate hypotheses about ancestral chromosome forms. Human chromosome 13 has been previously shown to be conserved as a single syntenic element in the Ancestral Primate Karyotype; in this context, in order to study and verify the conservation of primate chromosomes homologous to human chromosome 13, we mapped a selected set of BAC probes in three platyrrhine species, characterised by a high level of rearrangements, using fluorescence in situ hybridisation (FISH). Our mapping data on Saguinus oedipus, Callithrix argentata and Alouatta belzebul provide insight into synteny of human chromosome 13 evolution in a comparative perspective among primate species, showing rearrangements across taxa. Furthermore, in a wider perspective, we have revised previous cytogenomic literature data on chromosome 13 evolution in eutherian mammals, showing a complex origin of the eutherian mammal ancestral karyotype which has still not been completely clarified. Moreover, we analysed biomedical aspects (the OMIM and Mitelman databases) regarding human chromosome 13, showing that this autosome is characterised by a certain level of plasticity that has been implicated in many human cancers and diseases. View Full-Text
Keywords: FISH; evolution; human synteny; painting; BAC probes; plasticity FISH; evolution; human synteny; painting; BAC probes; plasticity
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MDPI and ACS Style

Scardino, R.; Milioto, V.; Proskuryakova, A.A.; Serdyukova, N.A.; Perelman, P.L.; Dumas, F. Evolution of the Human Chromosome 13 Synteny: Evolutionary Rearrangements, Plasticity, Human Disease Genes and Cancer Breakpoints. Genes 2020, 11, 383. https://doi.org/10.3390/genes11040383

AMA Style

Scardino R, Milioto V, Proskuryakova AA, Serdyukova NA, Perelman PL, Dumas F. Evolution of the Human Chromosome 13 Synteny: Evolutionary Rearrangements, Plasticity, Human Disease Genes and Cancer Breakpoints. Genes. 2020; 11(4):383. https://doi.org/10.3390/genes11040383

Chicago/Turabian Style

Scardino, Rita; Milioto, Vanessa; Proskuryakova, Anastasia A.; Serdyukova, Natalia A.; Perelman, Polina L.; Dumas, Francesca. 2020. "Evolution of the Human Chromosome 13 Synteny: Evolutionary Rearrangements, Plasticity, Human Disease Genes and Cancer Breakpoints" Genes 11, no. 4: 383. https://doi.org/10.3390/genes11040383

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