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Review

The Metabolization Profile of the CYP2D6 Gene in Amerindian Populations: A Review

1
Oncology Research Center, Federal University of Pará, Belém, Pará 66073, Brazil
2
Laboratory of Human and Medical Genetics, Institute of Biological Science, Federal University of Pará, Belém, Pará 66077-830, Brazil
*
Author to whom correspondence should be addressed.
Genes 2020, 11(3), 262; https://doi.org/10.3390/genes11030262
Received: 9 January 2020 / Revised: 4 February 2020 / Accepted: 14 February 2020 / Published: 28 February 2020
Background: the CYP2D6 gene is clinically important and is known to have a number of variants. This gene has four distinct metabolization profiles that are determined by the different allelic forms present in the individual. The relative frequency of these profiles varies considerably among human populations around the world. Populations from more isolated regions, such as Native Americans, are still relatively poorly studied, however. Even so, recent advances in genotyping techniques and increasing interest in the study of these populations has led to a progressive increase in publication rates. Given this, the review presented here compiled the principal papers published on the CYP2D6 gene in Amerindian populations to determine the metabolic profile of this group. Methods: a systematic literature review was conducted in three scientific publication platforms (Google Scholar, Science Direct, and Pubmed). The search was run using the keywords “CYP2D6 Amerindians” and “CYP2D6 native Americans”. Results: a total of 13 original papers met the inclusion criteria established for this study. All the papers presented frequencies of the different CYP2D6 alleles in Amerindian populations. Seven of the papers focused specifically on Amerindian populations from Mexico, while the others included populations from Argentina, Chile, Costa Rica, Mexico, Paraguay, Peru, and the United States. The results of the papers reviewed here showed that the extensive metabolization profile was the most prevalent in all Amerindian populations studied to date, followed by the intermediate, slow, and ultra-rapid, in that order. Conclusion: the metabolization profiles of the Amerindian populations reviewed in the present study do not diverge in any major way from those of other populations from around the world. Given the paucity of the data available on Amerindian populations, further research is required to better characterize the metabolization profile of these populations to ensure the development of adequate therapeutic strategies. View Full-Text
Keywords: Amerindians; CYP2D6; phenotype; genetic polymorphisms; metabolization profile; Native Americans Amerindians; CYP2D6; phenotype; genetic polymorphisms; metabolization profile; Native Americans
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MDPI and ACS Style

Leitão, L.P.C.; Souza, T.P.; Rodrigues, J.C.G.; Fernandes, M.R.; Santos, S.; Santos, N.P.C. The Metabolization Profile of the CYP2D6 Gene in Amerindian Populations: A Review. Genes 2020, 11, 262. https://doi.org/10.3390/genes11030262

AMA Style

Leitão LPC, Souza TP, Rodrigues JCG, Fernandes MR, Santos S, Santos NPC. The Metabolization Profile of the CYP2D6 Gene in Amerindian Populations: A Review. Genes. 2020; 11(3):262. https://doi.org/10.3390/genes11030262

Chicago/Turabian Style

Leitão, Luciana P.C., Tatiane P. Souza, Juliana C.G. Rodrigues, Marianne R. Fernandes, Sidney Santos, and Ney P.C. Santos. 2020. "The Metabolization Profile of the CYP2D6 Gene in Amerindian Populations: A Review" Genes 11, no. 3: 262. https://doi.org/10.3390/genes11030262

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