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Volume 11
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10.3390/genes11111352
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Article

The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing

by
Chong Chen
1,2,3,
Yuchun Li
4,
Ruiyang Tao
2,5,
Xiaoye Jin
1,
Yuxin Guo
1,
Wei Cui
3,
Anqi Chen
2,6,
Yue Yang
2,7,
Xingru Zhang
1,
Jingyi Zhang
2,
Chengtao Li
2,3,5,6,7,* and
Bofeng Zhu
1,3,8,*
1
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
2
Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai 200063, China
3
Multi-Omics Innovative Research Center of Forensic Identification, Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
4
State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
5
Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610017, China
6
Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai 200032, China
7
School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010030, China
8
College of Forensic Medicine, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
*
Authors to whom correspondence should be addressed.
Genes 2020, 11(11), 1352; https://doi.org/10.3390/genes11111352
Received: 10 October 2020 / Revised: 3 November 2020 / Accepted: 9 November 2020 / Published: 14 November 2020
(This article belongs to the Section Human Genomics and Genetic Diseases)
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Abstract

Mitochondrial DNA (mtDNA), coupled with maternal inheritance and relatively high mutation rates, provides a pivotal way for us to investigate the formation histories of populations. The Hui minority with Islamic faith is one of the most widely distributed ethnic groups in China. However, the exploration of Hui’s genetic architecture from the complete mitochondrial genome perspective has not been detected yet. Therefore, in this study, we employed the complete mitochondrial genomes of 98 healthy and unrelated individuals from Northwest China, as well as 99 previously published populations containing 7274 individuals from all over the world as reference data, to comprehensively dissect the matrilineal landscape of Hui group. Our results demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different regions, which was largely attributable to the widespread of haplogroups D4, D5, M7, B4, and F1 in these populations. The demographic expansion of Hui group might occur during the Late Pleistocene. Finally, we also found that Hui group might have gene exchanges with Uygur, Tibetan, and Tajik groups in different degrees and retain minor genetic imprint of European-specific lineages, therefore, hinting the existence of multi-ethnic integration events in shaping the genetic landscape of Chinese Hui group. View Full-Text
Keywords: complete mitochondrial genome; mitochondrial haplogroup; massively parallel sequencing; population genetics; Hui minority complete mitochondrial genome; mitochondrial haplogroup; massively parallel sequencing; population genetics; Hui minority
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MDPI and ACS Style

Chen, C.; Li, Y.; Tao, R.; Jin, X.; Guo, Y.; Cui, W.; Chen, A.; Yang, Y.; Zhang, X.; Zhang, J.; Li, C.; Zhu, B. The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing. Genes 2020, 11, 1352. https://doi.org/10.3390/genes11111352

AMA Style

Chen C, Li Y, Tao R, Jin X, Guo Y, Cui W, Chen A, Yang Y, Zhang X, Zhang J, Li C, Zhu B. The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing. Genes. 2020; 11(11):1352. https://doi.org/10.3390/genes11111352

Chicago/Turabian Style

Chen, Chong, Yuchun Li, Ruiyang Tao, Xiaoye Jin, Yuxin Guo, Wei Cui, Anqi Chen, Yue Yang, Xingru Zhang, Jingyi Zhang, Chengtao Li, and Bofeng Zhu. 2020. "The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing" Genes 11, no. 11: 1352. https://doi.org/10.3390/genes11111352

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