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Review

Features of DNA Repair in the Early Stages of Mammalian Embryonic Development

1
Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia
2
Institute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, Russia
3
Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia
4
Preclinical Research Center, University of Science and Technology, 1 Olympic Ave, 354340 Sochi, Russia
*
Author to whom correspondence should be addressed.
Genes 2020, 11(10), 1138; https://doi.org/10.3390/genes11101138
Received: 29 August 2020 / Revised: 20 September 2020 / Accepted: 25 September 2020 / Published: 27 September 2020
Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to dysfunction in certain tissues or organs, while a violation of genomic integrity during the embryonic period often leads to death. A mammalian embryo’s ability to respond to damaged DNA and repair it, as well as its sensitivity to specific lesions, is still not well understood. In this review, we combine disparate data on repair processes in the early stages of preimplantation development in mammalian embryos. View Full-Text
Keywords: DNA repair; BER (base excision repair); NER (nucleotide excision repair); MMR (mismatch repair); DSBR (double strand break repair); HR (homologous recombination); NHEJ (nonhomologous end joining); MHEJ (microhomologies end joining); oocyte; zygote; blastocyst DNA repair; BER (base excision repair); NER (nucleotide excision repair); MMR (mismatch repair); DSBR (double strand break repair); HR (homologous recombination); NHEJ (nonhomologous end joining); MHEJ (microhomologies end joining); oocyte; zygote; blastocyst
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MDPI and ACS Style

Khokhlova, E.V.; Fesenko, Z.S.; Sopova, J.V.; Leonova, E.I. Features of DNA Repair in the Early Stages of Mammalian Embryonic Development. Genes 2020, 11, 1138. https://doi.org/10.3390/genes11101138

AMA Style

Khokhlova EV, Fesenko ZS, Sopova JV, Leonova EI. Features of DNA Repair in the Early Stages of Mammalian Embryonic Development. Genes. 2020; 11(10):1138. https://doi.org/10.3390/genes11101138

Chicago/Turabian Style

Khokhlova, Evgenia V., Zoia S. Fesenko, Julia V. Sopova, and Elena I. Leonova 2020. "Features of DNA Repair in the Early Stages of Mammalian Embryonic Development" Genes 11, no. 10: 1138. https://doi.org/10.3390/genes11101138

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