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Open AccessArticle

PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis

1
Department of Medical Biochemistry, Oslo University Hospital, 0372 Oslo, Norway
2
Department of Medical Biochemistry, Institute for Clinical Medicine, University of Oslo, 0372 Oslo, Norway
3
Department of Newborn Screening, Division of Child and Adolescent Medicine, Oslo University Hospital, 0372 Oslo, Norway
4
Department of Microbiology, Oslo University Hospital, 0373 Oslo, Norway
5
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway
*
Author to whom correspondence should be addressed.
Genes 2020, 11(10), 1130; https://doi.org/10.3390/genes11101130
Received: 10 August 2020 / Revised: 13 September 2020 / Accepted: 17 September 2020 / Published: 25 September 2020
(This article belongs to the Section Animal Genetics and Genomics)
The promyelocytic leukemia (PML) protein is an essential component of nuclear compartments called PML bodies. This protein participates in several cellular processes, including growth control, senescence, apoptosis, and differentiation. Previous studies have suggested that PML regulates gene expression at a subset of loci through a function in chromatin remodeling. Here we have studied global gene expression patterns in mouse embryonic skin derived from Pml depleted and wild type mouse embryos. Differential gene expression analysis at different developmental stages revealed a key role of PML in regulating genes involved in epidermal stratification. In particular, we observed dysregulation of the late cornified envelope gene cluster, which is a sub-region of the epidermal differentiation complex. In agreement with these data, PML body numbers are elevated in basal keratinocytes during embryogenesis, and we observed reduced epidermal thickness and defective hair follicle development in PML depleted mouse embryos. View Full-Text
Keywords: PML; promyelocytic leukemia; EDC/epidermal differentiation complex; epidermis; keratinocytes; skin; mouse embryo; development PML; promyelocytic leukemia; EDC/epidermal differentiation complex; epidermis; keratinocytes; skin; mouse embryo; development
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Połeć, A.; Rowe, A.D.; Blicher, P.; Suganthan, R.; Bjørås, M.; Bøe, S.O. PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis. Genes 2020, 11, 1130.

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