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Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies
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ATM Serine/Threonine Kinase and its Role in Pancreatic Risk

by Neha Nanda 1,2 and Nicholas J. Roberts 1,2,3,*
1
Department of Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA
2
The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
3
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(1), 108; https://doi.org/10.3390/genes11010108
Received: 26 November 2019 / Revised: 10 January 2020 / Accepted: 12 January 2020 / Published: 17 January 2020
(This article belongs to the Special Issue Genetic Markers in Pancreatic Cancer)
Next-generation sequencing has led to the recent discovery of several novel pancreatic cancer susceptibility genes. These genes include ataxia telangiectasia mutated (ATM), a serine/threonine kinase that is an integral component of DNA repair. Pathogenic germline ATM variants are frequently identified in patients with pancreatic ductal adenocarcinoma (PDAC) with and without a family history of the disease. Loss of ATM is also a frequent somatic event in the development of PDAC. These discoveries have advanced our understanding of the genetic basis of pancreatic cancer risk and will impact patient care through appropriate patient–risk stratification; personalized screening and early detection efforts; and, for some, targeted therapy. View Full-Text
Keywords: ATM; pancreatic ductal adenocarcinoma; pancreatic cancer; genetics; predisposition ATM; pancreatic ductal adenocarcinoma; pancreatic cancer; genetics; predisposition
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Nanda, N.; Roberts, N.J. ATM Serine/Threonine Kinase and its Role in Pancreatic Risk. Genes 2020, 11, 108.

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