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Genes 2019, 10(3), 249; https://doi.org/10.3390/genes10030249

Does the Presence of Transposable Elements Impact the Epigenetic Environment of Human Duplicated Genes?

1
Laboratoire de Biométrie et Biologie Evolutive UMR 5558, Université de Lyon, Université Lyon 1, CNRS, F-69622 Villeurbanne, France
2
Laboratoire de Mathématiques et Modélisation d’Evry (LaMME), Université d’Evry Val d’Essonne, UMR CNRS 8071, ENSIIE, USC INRA, 23 bvd de France, 91037 Evry CEDEX Paris, France
*
Author to whom correspondence should be addressed.
Present Address: Institut de Biologie Paris-Seine (IBPS), Sorbonne Universites, UPMC Universite Paris 06, 75005 Paris, France.
Received: 29 January 2019 / Revised: 22 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Repetitive DNA Sequences)
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Abstract

Epigenetic modifications have an important role to explain part of the intra- and inter-species variation in gene expression. They also have a role in the control of transposable elements (TEs) whose activity may have a significant impact on genome evolution by promoting various mutations, which are expected to be mostly deleterious. A change in the local epigenetic landscape associated with the presence of TEs is expected to affect the expression of neighboring genes since these modifications occurring at TE sequences can spread to neighboring sequences. In this work, we have studied how the epigenetic modifications of genes are conserved and what the role of TEs is in this conservation. For that, we have compared the conservation of the epigenome associated with human duplicated genes and the differential presence of TEs near these genes. Our results show higher epigenome conservation of duplicated genes from the same family when they share similar TE environment, suggesting a role for the differential presence of TEs in the evolutionary divergence of duplicates through variation in the epigenetic landscape. View Full-Text
Keywords: transposable elements; gene duplication; gene evolution; epigenetics transposable elements; gene duplication; gene evolution; epigenetics
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Lannes, R.; Rizzon, C.; Lerat, E. Does the Presence of Transposable Elements Impact the Epigenetic Environment of Human Duplicated Genes? Genes 2019, 10, 249.

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