Next Article in Journal
Novel Insights into Plant Genome Evolution and Adaptation as Revealed through Transposable Elements and Non-Coding RNAs in Conifers
Next Article in Special Issue
Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity
Previous Article in Journal
Knockdown of Cytochrome P450 Genes Gh_D07G1197 and Gh_A13G2057 on Chromosomes D07 and A13 Reveals Their Putative Role in Enhancing Drought and Salt Stress Tolerance in Gossypium hirsutum
Previous Article in Special Issue
The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Open AccessArticle

Exceptional Longevity and Polygenic Risk for Cardiovascular Health

1
Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW 2031, Australia
2
Neuroscience Research Australia, Randwick, NSW 2031, Australia
3
Hunter Medical Research Institute, Newcastle, NSW 2305, Australia
4
Discipline of Mathematics and Statistics, Murdoch University, Perth, WA 6150, Australia
5
Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia
6
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
7
Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW 2052, Australia
8
Pathology North, John Hunter Hospital, Newcastle, NSW 2305, Australia
9
Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
*
Author to whom correspondence should be addressed.
Genes 2019, 10(3), 227; https://doi.org/10.3390/genes10030227
Received: 31 January 2019 / Revised: 13 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Genetic Determinants of Human Longevity)
Studies investigating exceptionally long-lived (ELL) individuals, including genetic studies, have linked cardiovascular-related pathways, particularly lipid and cholesterol homeostasis, with longevity. This study explored the genetic profiles of ELL individuals (cases: n = 294, 95–106 years; controls: n = 1105, 55–65 years) by assessing their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of p < 5 × 10−5. PRS were constructed using GWAS summary data from two exceptional longevity (EL) analyses and eight cardiovascular-related risk factors (lipids) and disease (myocardial infarction, coronary artery disease, stroke) analyses. A higher genetic risk for exceptional longevity (EL) was significantly associated with longevity in our sample (odds ratio (OR) = 1.19–1.20, p = 0.00804 and 0.00758, respectively). Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing. In conclusion, ELL individuals did not have significantly lower polygenic risk for the majority of the investigated cardiovascular health traits. Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL. View Full-Text
Keywords: polygenic risk score; cardiovascular health; exceptional longevity; lipid profile polygenic risk score; cardiovascular health; exceptional longevity; lipid profile
Show Figures

Figure 1

MDPI and ACS Style

Revelas, M.; Thalamuthu, A.; Oldmeadow, C.; Evans, T.-J.; Armstrong, N.J.; Riveros, C.; Kwok, J.B.; Schofield, P.R.; Brodaty, H.; Scott, R.J.; Attia, J.R.; Sachdev, P.S.; Mather, K.A. Exceptional Longevity and Polygenic Risk for Cardiovascular Health. Genes 2019, 10, 227.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop