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The Roles of Hypoxia-Inducible Factors and Non-Coding RNAs in Gastrointestinal Cancer

by Hyun-Soo Cho 1,†, Tae-Su Han 1,†, Keun Hur 2,* and Hyun Seung Ban 1,*
1
Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
2
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41944, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2019, 10(12), 1008; https://doi.org/10.3390/genes10121008
Received: 10 November 2019 / Revised: 26 November 2019 / Accepted: 2 December 2019 / Published: 4 December 2019
(This article belongs to the Special Issue Non-coding RNAs: Variety of Roles and Applications in Human Diseases)
Hypoxia-inducible factors (HIFs) are transcription factors that play central roles in cellular responses against hypoxia. In most cancers, HIFs are closely associated with tumorigenesis by regulating cell survival, angiogenesis, metastasis, and adaptation to the hypoxic tumor microenvironment. Recently, non-coding RNAs (ncRNAs) have been reported to play critical roles in the hypoxic response in various cancers. Here, we review the roles of hypoxia-response ncRNAs in gastrointestinal cancer, with a particular focus on microRNAs and long ncRNAs, and discuss the functional relationships and regulatory mechanisms between HIFs and ncRNAs.
Keywords: hypoxia; non-coding RNA; microRNA; hypoxia-inducible factor; gastrointestinal cancer hypoxia; non-coding RNA; microRNA; hypoxia-inducible factor; gastrointestinal cancer
MDPI and ACS Style

Cho, H.-S.; Han, T.-S.; Hur, K.; Ban, H.S. The Roles of Hypoxia-Inducible Factors and Non-Coding RNAs in Gastrointestinal Cancer. Genes 2019, 10, 1008.

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