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Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer

Bungtown Road, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
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Genes 2019, 10(10), 794; https://doi.org/10.3390/genes10100794
Received: 15 September 2019 / Revised: 5 October 2019 / Accepted: 8 October 2019 / Published: 12 October 2019
(This article belongs to the Section Human Genomics and Genetic Diseases)
Development requires the careful orchestration of several biological events in order to create any structure and, eventually, to build an entire organism. On the other hand, the fate transformation of terminally differentiated cells is a consequence of erroneous development, and ultimately leads to cancer. In this review, we elaborate how development and cancer share several biological processes, including molecular controls. Transcription factors (TF) are at the helm of both these processes, among many others, and are evolutionarily conserved, ranging from yeast to humans. Here, we discuss four families of TFs that play a pivotal role and have been studied extensively in both embryonic development and cancer—high mobility group box (HMG), GATA, paired box (PAX) and basic helix-loop-helix (bHLH) in the context of their role in development, cancer, and their conservation across several species. Finally, we review TFs as possible therapeutic targets for cancer and reflect on the importance of natural resistance against cancer in certain organisms, yielding knowledge regarding TF function and cancer biology. View Full-Text
Keywords: transcription factors; embryonic development; evolution; cancer; clinical trials; high mobility group box (HMG); basic helix loop helix (bHLH); paired box (Pax); GATA transcription factors; embryonic development; evolution; cancer; clinical trials; high mobility group box (HMG); basic helix loop helix (bHLH); paired box (Pax); GATA
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Huilgol, D.; Venkataramani, P.; Nandi, S.; Bhattacharjee, S. Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer. Genes 2019, 10, 794.

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