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MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential

1
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
2
Department of Biotechnology, Kumaun University, Nainital, Uttarakhand 263001, India
3
Department of Internal Medicine, Loyola University Medical Center, Chicago, IL 60153, USA
4
Biosecurity and Public Health Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
5
Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(10), 752; https://doi.org/10.3390/genes10100752
Received: 31 July 2019 / Revised: 19 September 2019 / Accepted: 20 September 2019 / Published: 25 September 2019
(This article belongs to the Special Issue The Role of Genotoxicity in Infertility and Cancer Development)
Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions. View Full-Text
Keywords: microRNA; pancreatic cancer; diagnosis; prognosis; potential therapeutic targets microRNA; pancreatic cancer; diagnosis; prognosis; potential therapeutic targets
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MDPI and ACS Style

Rawat, M.; Kadian, K.; Gupta, Y.; Kumar, A.; Chain, P.S.; Kovbasnjuk, O.; Kumar, S.; Parasher, G. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. Genes 2019, 10, 752.

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