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Genes 2010, 1(2), 308-316;

TSPY and Male Fertility

Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Endocrine Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
Author to whom correspondence should be addressed.
Received: 7 July 2010 / Revised: 1 September 2010 / Accepted: 14 September 2010 / Published: 21 September 2010
(This article belongs to the Special Issue The TSPY Gene Family)
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Spermatogenesis requires the concerted action of thousands of genes, all contributing to its efficiency to a different extent. The Y chromosome contains several testis-specific genes and among them the AZF region genes on the Yq and the TSPY1 array on the Yp are the most relevant candidates for spermatogenic function. TSPY1 was originally described as the putative gene for the gonadoblastoma locus on the Y (GBY) chromosome. Besides its oncogenic properties, expression analyses in the testis and in vitro and in vivo studies all converge on a physiological involvement of the TSPY1 protein in spermatogenesis as a pro-proliferative factor. The majority of TSPY1 copies are arranged in 20.4 kb of tandemly repeated units, with different copy numbers among individuals. Our recent study addressing the role of TSPY1 copy number variation in spermatogenesis reported that TSPY1 copy number influences spermatogenic efficiency and is positively correlated with sperm count. This finding provides further evidence for a role of TSPY1 in testicular germ cell proliferation and stimulates future research aimed at evaluating the relationship between the copy number and the protein expression level of the TSPY1 gene. View Full-Text
Keywords: TSPY; genetics; male infertility; Y chromosome; spermatogenesis TSPY; genetics; male infertility; Y chromosome; spermatogenesis

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Krausz, C.; Giachini, C.; Forti, G. TSPY and Male Fertility. Genes 2010, 1, 308-316.

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