Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems
Abstract
:1. Introduction
2. Microglia in the Healthy Central Nervous System
3. Microglia in the Pathological CNS
3.1. Heterogeneity of Microglia in Traumatic Brain Injury and Cerebral Infarction
3.2. Metabolic Changes in Microglia in TBI and Infarction
3.3. Phagocytosis by Microglia and Find-Me/Eat-Me Signals in TBI and Infarction
3.4. Oxidative Stress Caused by Microglia and Macrophages in TBI and Infarction
3.5. Heterogeneity of Blood-Borne Macrophages in TBI and Infarction
3.6. Carbon Monoxide Poisoning
4. Microglia/Macrophages in the PNS Injury
5. Therapeutic Approaches Targeting Microglia
5.1. Immunomodulation
5.1.1. Suppressing the Proinflammatory Reaction of Microglia/Macrophages
5.1.2. Enhancing the Neuroprotective Function of Microglia/Macrophages
5.2. Controlling Metabolism of Microglia/Macrophages
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Abe, N.; Nishihara, T.; Yorozuya, T.; Tanaka, J. Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems. Cells 2020, 9, 2132. https://doi.org/10.3390/cells9092132
Abe N, Nishihara T, Yorozuya T, Tanaka J. Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems. Cells. 2020; 9(9):2132. https://doi.org/10.3390/cells9092132
Chicago/Turabian StyleAbe, Naoki, Tasuku Nishihara, Toshihiro Yorozuya, and Junya Tanaka. 2020. "Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems" Cells 9, no. 9: 2132. https://doi.org/10.3390/cells9092132