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Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System
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Schwann Cell Role in Selectivity of Nerve Regeneration

Institute of Neurosciences, Department Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 08193 Bellaterra, Spain
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Cells 2020, 9(9), 2131; https://doi.org/10.3390/cells9092131
Received: 6 August 2020 / Revised: 16 September 2020 / Accepted: 17 September 2020 / Published: 20 September 2020
(This article belongs to the Special Issue Schwann Cells: From Formation to Clinical Significance)
Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating axons respond to their environment and direct their growth is essential to improve the functional outcome of patients with nerve lesions. Schwann cells (SCs) play a crucial role in the regeneration process, but little is known about their contribution to specific reinnervation. Here, we review the mechanisms by which SCs can differentially influence the regeneration of motor and sensory axons. Mature SCs express modality-specific phenotypes that have been associated with the promotion of selective regeneration. These include molecular markers, such as L2/HNK-1 carbohydrate, which is differentially expressed in motor and sensory SCs, or the neurotrophic profile after denervation, which differs remarkably between SC modalities. Other important factors include several molecules implicated in axon-SC interaction. This cell–cell communication through adhesion (e.g., polysialic acid) and inhibitory molecules (e.g., MAG) contributes to guiding growing axons to their targets. As many of these factors can be modulated, further research will allow the design of new strategies to improve functional recovery after peripheral nerve injuries. View Full-Text
Keywords: axon; Schwann cell; regeneration; axon-glia interactions; peripheral nerve injury; reinnervation accuracy; preferential motor reinnervation; motor; sensory axon; Schwann cell; regeneration; axon-glia interactions; peripheral nerve injury; reinnervation accuracy; preferential motor reinnervation; motor; sensory
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MDPI and ACS Style

Bolívar, S.; Navarro, X.; Udina, E. Schwann Cell Role in Selectivity of Nerve Regeneration. Cells 2020, 9, 2131. https://doi.org/10.3390/cells9092131

AMA Style

Bolívar S, Navarro X, Udina E. Schwann Cell Role in Selectivity of Nerve Regeneration. Cells. 2020; 9(9):2131. https://doi.org/10.3390/cells9092131

Chicago/Turabian Style

Bolívar, Sara, Xavier Navarro, and Esther Udina. 2020. "Schwann Cell Role in Selectivity of Nerve Regeneration" Cells 9, no. 9: 2131. https://doi.org/10.3390/cells9092131

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