Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering
1
Institute of Neuroanatomy and Cell Biology, Hannover Medical School, 30623 Hannover, Germany
2
Center for Systems Neuroscience (ZSN) Hannover, 30559 Hannover, Germany
3
Department of Pharmacology, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK
4
UCL Centre for Nerve Engineering, University College London, London WC1E 6BT, UK
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to the manuscript.
‡
J.B.P. and K.H.-T. share senior authorship.
Cells 2020, 9(11), 2497; https://doi.org/10.3390/cells9112497
Received: 22 October 2020
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Revised: 13 November 2020
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Accepted: 16 November 2020
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Published: 17 November 2020
(This article belongs to the Special Issue Schwann Cells: From Formation to Clinical Significance)
Schwann cells play a crucial role in successful peripheral nerve repair and regeneration by supporting both axonal growth and myelination. Schwann cells are therefore a feasible option for cell therapy treatment of peripheral nerve injury. However, sourcing human Schwann cells at quantities required for development beyond research is challenging. Due to their availability, rapid in vitro expansion, survival, and integration within the host tissue, stem cells have attracted considerable attention as candidate cell therapies. Among them, induced pluripotent stem cells (iPSCs) with the associated prospects for personalized treatment are a promising therapy to take the leap from bench to bedside. In this critical review, we firstly focus on the current knowledge of the Schwann cell phenotype in regard to peripheral nerve injury, including crosstalk with the immune system during peripheral nerve regeneration. Then, we review iPSC to Schwann cell derivation protocols and the results from recent in vitro and in vivo studies. We finally conclude with some prospects for the use of iPSCs in clinical settings.
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MDPI and ACS Style
Huang, Z.; Powell, R.; Phillips, J.B.; Haastert-Talini, K. Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering. Cells 2020, 9, 2497. https://doi.org/10.3390/cells9112497
AMA Style
Huang Z, Powell R, Phillips JB, Haastert-Talini K. Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering. Cells. 2020; 9(11):2497. https://doi.org/10.3390/cells9112497
Chicago/Turabian StyleHuang, Zhong, Rebecca Powell, James B. Phillips, and Kirsten Haastert-Talini. 2020. "Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering" Cells 9, no. 11: 2497. https://doi.org/10.3390/cells9112497
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