Next Article in Journal
Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast
Next Article in Special Issue
Increased Uptake of Silica Nanoparticles in Inflamed Macrophages but Not upon Co-Exposure to Micron-Sized Particles
Previous Article in Journal
The Amazonian Red Side-Necked Turtle Rhinemys rufipes (Spix, 1824) (Testudines, Chelidae) Has a GSD Sex-Determining Mechanism with an Ancient XY Sex Microchromosome System
Previous Article in Special Issue
Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
Open AccessArticle

Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells

1
Department of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz, Germany
2
Max Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, Germany
3
Dermatology Clinic, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(9), 2087; https://doi.org/10.3390/cells9092087
Received: 1 August 2020 / Revised: 1 September 2020 / Accepted: 9 September 2020 / Published: 12 September 2020
(This article belongs to the Special Issue Nanoparticles in Cancer Immunotherapy)
Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used. View Full-Text
Keywords: carbohydrates; glycodendrons; dendritic cells; nanocapsules; cell targeting carbohydrates; glycodendrons; dendritic cells; nanocapsules; cell targeting
Show Figures

Figure 1

MDPI and ACS Style

Krumb, M.; Frey, M.-L.; Langhanki, J.; Forster, R.; Kowalczyk, D.; Mailänder, V.; Landfester, K.; Opatz, T. Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells. Cells 2020, 9, 2087.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop