Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment
Abstract
:1. Introduction
2. NMII: From Structure to Regulation and Function
2.1. NMII Isoforms and Structure
2.2. NMII Regulation and Function
2.3. NMII: From Filament Formation to Stacks
3. Actomyosin in Neurons
3.1. NMII: From Neurite Formation during Neuronal Polarization to Axon Regeneration in the Adult
3.1.1. The Actomyosin Cytoskeleton in the Growth Cone
3.1.2. The Role of NMII in Growth Cone-Mediated Axon Elongation
3.1.3. NMIIA and NMIIB Play Central Roles in Axon Guidance
3.1.4. NMII as a Modulator of Axon Regeneration in the Adult
3.2. Distribution of NMII Throughout the Axon Shaft: From Enrichment in the AIS to Its Presence Throughout the Axon Shaft
3.2.1. Why Is Active NMII Enriched in the AIS?
3.2.2. The Actomyosin Cytoskeleton as a Key Regulator of Circumferential and Longitudinal Axonal Tension
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Costa, A.R.; Sousa, M.M. Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment. Cells 2020, 9, 1961. https://doi.org/10.3390/cells9091961
Costa AR, Sousa MM. Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment. Cells. 2020; 9(9):1961. https://doi.org/10.3390/cells9091961
Chicago/Turabian StyleCosta, Ana Rita, and Monica M. Sousa. 2020. "Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment" Cells 9, no. 9: 1961. https://doi.org/10.3390/cells9091961