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Oncology Therapeutics Targeting the Metabolism of Amino Acids

Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(8), 1904; https://doi.org/10.3390/cells9081904
Received: 27 July 2020 / Revised: 12 August 2020 / Accepted: 13 August 2020 / Published: 15 August 2020
(This article belongs to the Special Issue New Aspects of Targeting Cancer Metabolism in Therapeutic Approach)
Amino acid metabolism promotes cancer cell proliferation and survival by supporting building block synthesis, producing reducing agents to mitigate oxidative stress, and generating immunosuppressive metabolites for immune evasion. Malignant cells rewire amino acid metabolism to maximize their access to nutrients. Amino acid transporter expression is upregulated to acquire amino acids from the extracellular environment. Under nutrient depleted conditions, macropinocytosis can be activated where proteins from the extracellular environment are engulfed and degraded into the constituent amino acids. The demand for non-essential amino acids (NEAAs) can be met through de novo synthesis pathways. Cancer cells can alter various signaling pathways to boost amino acid usage for the generation of nucleotides, reactive oxygen species (ROS) scavenging molecules, and oncometabolites. The importance of amino acid metabolism in cancer proliferation makes it a potential target for therapeutic intervention, including via small molecules and antibodies. In this review, we will delineate the targets related to amino acid metabolism and promising therapeutic approaches. View Full-Text
Keywords: cancer metabolism; amino acids; oncogenic therapeutics cancer metabolism; amino acids; oncogenic therapeutics
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MDPI and ACS Style

Muhammad, N.; Lee, H.M.; Kim, J. Oncology Therapeutics Targeting the Metabolism of Amino Acids. Cells 2020, 9, 1904. https://doi.org/10.3390/cells9081904

AMA Style

Muhammad N, Lee HM, Kim J. Oncology Therapeutics Targeting the Metabolism of Amino Acids. Cells. 2020; 9(8):1904. https://doi.org/10.3390/cells9081904

Chicago/Turabian Style

Muhammad, Nefertiti; Lee, Hyun M.; Kim, Jiyeon. 2020. "Oncology Therapeutics Targeting the Metabolism of Amino Acids" Cells 9, no. 8: 1904. https://doi.org/10.3390/cells9081904

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