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Article

The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
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Cells 2020, 9(8), 1774; https://doi.org/10.3390/cells9081774
Received: 3 June 2020 / Revised: 29 June 2020 / Accepted: 23 July 2020 / Published: 24 July 2020
(This article belongs to the Special Issue Mitochondrial Permeability Transition)
Decades of active research have shown that mitochondrial dysfunction, the associated oxidative stress, impaired anti-stress defense mechanisms, and the activation of the proapoptotic signaling pathways underlie pathological changes in organs and tissues. Pathologies caused by alcohol primarily affect the liver. Alcohol abuse is the cause of many liver diseases, such as steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis, and, potentially, hepatocellular cancer. In this study, the effect of chronic alcohol exposure on rat liver mitochondria was investigated. We observed an ethanol-induced increase in sensitivity to calcium, changes in the level of protein kinase Akt and GSK-3β phosphorylation, an induction of the mitochondrial permeability transition pore (mPTP), and strong alterations in the expression of mPTP regulators. Moreover, we also showed an enhanced effect of PK11195 and PPIX, on the parameters of the mPTP opening in rat liver mitochondria (RLM) isolated from ethanol-treated rats compared to the RLM from control rats. We suggest that the results of this study could help elucidate the mechanisms of chronic ethanol action on the mitochondria and contribute to the development of new therapeutic strategies for treating the effects of ethanol-related diseases. View Full-Text
Keywords: rat liver mitochondria (RLM); chronic ethanol intoxication; translocator protein (TSPO); 2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase); mitochondrial permeability transition pore (mPTP) rat liver mitochondria (RLM); chronic ethanol intoxication; translocator protein (TSPO); 2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase); mitochondrial permeability transition pore (mPTP)
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MDPI and ACS Style

Baburina, Y.; Odinokova, I.; Krestinina, O. The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore. Cells 2020, 9, 1774. https://doi.org/10.3390/cells9081774

AMA Style

Baburina Y, Odinokova I, Krestinina O. The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore. Cells. 2020; 9(8):1774. https://doi.org/10.3390/cells9081774

Chicago/Turabian Style

Baburina, Yulia, Irina Odinokova, and Olga Krestinina. 2020. "The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore" Cells 9, no. 8: 1774. https://doi.org/10.3390/cells9081774

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