Next Article in Journal
Emerging Roles of Inhibitor of Differentiation-1 in Alzheimer’s Disease: Cell Cycle Reentry and Beyond
Previous Article in Journal
Hydrodynamics-Based Transplacental Delivery as a Useful Noninvasive Tool for Manipulating Fetal Genome
Article

Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle

1
Department of Biochemistry and Cell Biology, University of Rzeszów, 35-601 Rzeszów, Poland
2
Department of Molecular Biology, Maria Curie-Skłodowska University, 20-033 Lublin, Poland
3
The Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, 30-239 Krakow, Poland
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(7), 1745; https://doi.org/10.3390/cells9071745
Received: 12 June 2020 / Revised: 6 July 2020 / Accepted: 16 July 2020 / Published: 21 July 2020
Aging is a biological phenomenon common to all living organisms. It is thought that the rate of aging is influenced by diverse factors, in many cases related to the control of energy metabolism, i.e., the so-called pro-longevity effects of starvation. Translation, regarded as the main energy consumption process, lies at the center of interest, as it has a significant impact on the longevity phenomenon. It has been shown that perturbations in the translational apparatus may lead to a lower rate of aging. Therefore, the main aim of this study was to investigate aging in relation to the protein biosynthesis circuit, taking into account the uL11 ribosomal protein as a vital ribosomal element. To this end, we used set of yeast mutants with deleted single uL11A or uL11B genes and a double disruptant uL11AB mutant. We applied an integrated approach analyzing a broad range of biological parameters of yeast mutant cells, especially the longevity phenomenon, supplemented with biochemical and high throughput transcriptomic and metobolomic approaches. The analysis showed that the longevity phenomenon is not fully related to the commonly considered energy restriction effect, thus the slow-down of translation does not represent the sole source of aging. Additionally, we showed that uL11 can be classified as a moonlighting protein with extra-ribosomal function having cell-cycle regulatory potential. View Full-Text
Keywords: uL11; paralogs; ribosome; translation; aging; lifespan; hypertrophy; cell-cycle uL11; paralogs; ribosome; translation; aging; lifespan; hypertrophy; cell-cycle
Show Figures

Figure 1

MDPI and ACS Style

Mołoń, M.; Molestak, E.; Kula-Maximenko, M.; Grela, P.; Tchórzewski, M. Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle. Cells 2020, 9, 1745. https://doi.org/10.3390/cells9071745

AMA Style

Mołoń M, Molestak E, Kula-Maximenko M, Grela P, Tchórzewski M. Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle. Cells. 2020; 9(7):1745. https://doi.org/10.3390/cells9071745

Chicago/Turabian Style

Mołoń, Mateusz, Eliza Molestak, Monika Kula-Maximenko, Przemysław Grela, and Marek Tchórzewski. 2020. "Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle" Cells 9, no. 7: 1745. https://doi.org/10.3390/cells9071745

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop