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Peer-Review Record

In Vitro Modeling of Reoxygenation Effects on mRNA and Protein Levels in Hypoxic Tumor Cells upon Entry into the Bloodstream

Cells 2020, 9(5), 1316; https://doi.org/10.3390/cells9051316
by Kai Bartkowiak, Claudia Koch, Sebastian Gärtner, Antje Andreas, Tobias M Gorges and Klaus Pantel *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cells 2020, 9(5), 1316; https://doi.org/10.3390/cells9051316
Submission received: 20 April 2020 / Revised: 11 May 2020 / Accepted: 20 May 2020 / Published: 25 May 2020

Round 1

Reviewer 1 Report

The data added in this revision does not connect with the rest of the story. The conclusions are still poorly supported. The manuscript is now extremely long and although it brings some biological observations relative to mRNA/protein expression in chronic hypoxia/reoxygenation, it does not bring a meaningful well-corroborated biological conclusion. It is extremely important to include blots of HIF-1a and HIF-2a when studying hypoxia/reoxygenation effects. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors have now addressed my comments.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

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