Next Article in Journal
IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells
Next Article in Special Issue
Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain
Previous Article in Journal
Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy
Previous Article in Special Issue
NeuroHeal Treatment Alleviates Neuropathic Pain and Enhances Sensory Axon Regeneration
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Cells
Volume 9
Issue 4
10.3390/cells9041007
cells-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain

by
Hodaya Leibovich
1,2,
Nahum Buzaglo
1,
Shlomo Tsuriel
1,2,
Liat Peretz
1,2,
Yaki Caspi
1,2,
Ben Katz
1,2,
Shaya Lev
1,2,
David Lichtstein
1 and
Alexander M. Binshtok
1,2,*
1
Department of Medical Neurobiology, Institute for Medical Research Israel Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
2
The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91120, Israel
*
Author to whom correspondence should be addressed.
Cells 2020, 9(4), 1007; https://doi.org/10.3390/cells9041007
Received: 17 March 2020 / Revised: 10 April 2020 / Accepted: 14 April 2020 / Published: 18 April 2020
(This article belongs to the Special Issue Novel Insights into Molecular Mechanisms of Chronic Pain)
View Full-Text Download PDF
Browse Figures

Abstract

An injury to peripheral nerves leads to skin denervation, which often is followed by increased pain sensitivity of the denervated areas and the development of neuropathic pain. Changes in innervation patterns during the reinnervation process of the denervated skin could contribute to the development of neuropathic pain. Here, we examined the changes in the innervation pattern during reinnervation and correlated them with the symptoms of neuropathic pain. Using a multispectral labeling technique—PainBow, which we developed, we characterized dorsal root ganglion (DRG) neurons innervating distinct areas of the rats’ paw. We then used spared nerve injury, causing partial denervation of the paw, and examined the changes in innervation patterns of the denervated areas during the development of allodynia and hyperalgesia. We found that, differently from normal conditions, during the development of neuropathic pain, these areas were mainly innervated by large, non-nociceptive neurons. Moreover, we found that the development of neuropathic pain is correlated with an overall decrease in the number of DRG neurons innervating these areas. Importantly, treatment with ouabain facilitated reinnervation and alleviated neuropathic pain. Our results suggest that local changes in peripheral innervation following denervation contribute to neuropathic pain development. The reversal of these changes decreases neuropathic pain. View Full-Text
Keywords: neuropathic pain; SNI; retrograde labeling; ouabain; reinnervation; denervation; sprouting; PNS; nociceptive; non-nociceptive neuropathic pain; SNI; retrograde labeling; ouabain; reinnervation; denervation; sprouting; PNS; nociceptive; non-nociceptive
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Leibovich, H.; Buzaglo, N.; Tsuriel, S.; Peretz, L.; Caspi, Y.; Katz, B.; Lev, S.; Lichtstein, D.; Binshtok, A.M. Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain. Cells 2020, 9, 1007. https://doi.org/10.3390/cells9041007

AMA Style

Leibovich H, Buzaglo N, Tsuriel S, Peretz L, Caspi Y, Katz B, Lev S, Lichtstein D, Binshtok AM. Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain. Cells. 2020; 9(4):1007. https://doi.org/10.3390/cells9041007

Chicago/Turabian Style

Leibovich, Hodaya, Nahum Buzaglo, Shlomo Tsuriel, Liat Peretz, Yaki Caspi, Ben Katz, Shaya Lev, David Lichtstein, and Alexander M. Binshtok. 2020. "Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain" Cells 9, no. 4: 1007. https://doi.org/10.3390/cells9041007

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop