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Review

Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine?

1
Section of Biology and Genetics, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Via Divisi 83, 90133 Palermo, Italy
2
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Bld. 16, 90128 Palermo, Italy
*
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1163; https://doi.org/10.3390/cells9051163
Received: 13 April 2020 / Revised: 2 May 2020 / Accepted: 4 May 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Therapeutic Applications of Extracellular Vesicles)
Regenerative medicine aims to repair damaged, tissues or organs for the treatment of various diseases, which have been poorly managed with conventional drugs and medical procedures. To date, multimodal regenerative methods include transplant of healthy organs, tissues, or cells, body stimulation to activate a self-healing response in damaged tissues, as well as the combined use of cells and bio-degradable scaffold to obtain functional tissues. Certainly, stem cells are promising tools in regenerative medicine due to their ability to induce de novo tissue formation and/or promote organ repair and regeneration. Currently, several studies have shown that the beneficial stem cell effects, especially for mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) in damaged tissue restore are not dependent on their engraftment and differentiation on the injury site, but rather to their paracrine activity. It is now well known that paracrine action of stem cells is due to their ability to release extracellular vesicles (EVs). EVs play a fundamental role in cell-to-cell communication and are directly involved in tissue regeneration. In the present review, we tried to summarize the molecular mechanisms through which MSCs and iPSCs-derived EVs carry out their therapeutic action and their possible application for the treatment of several diseases. View Full-Text
Keywords: extracellular vesicles; stem cells; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); regenerative medicine extracellular vesicles; stem cells; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); regenerative medicine
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MDPI and ACS Style

Barreca, M.M.; Cancemi, P.; Geraci, F. Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine? Cells 2020, 9, 1163. https://doi.org/10.3390/cells9051163

AMA Style

Barreca MM, Cancemi P, Geraci F. Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine? Cells. 2020; 9(5):1163. https://doi.org/10.3390/cells9051163

Chicago/Turabian Style

Barreca, Maria M., Patrizia Cancemi, and Fabiana Geraci. 2020. "Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine?" Cells 9, no. 5: 1163. https://doi.org/10.3390/cells9051163

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