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Perspective

Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use

1
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
2
Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Department of Internal Medicine and Therapeutics, Pneumology Unit IRCCS San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy
3
Pneumology Unit IRCCS San Matteo Hospital Foundation, 27100 Pavia, Italy
4
PharmaExceed S.r.l., 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Cells 2020, 9(4), 924; https://doi.org/10.3390/cells9040924
Received: 21 March 2020 / Revised: 7 April 2020 / Accepted: 8 April 2020 / Published: 9 April 2020
From the end of 2019, the world population has been faced the spread of the novel coronavirus SARS-CoV-2 responsible for COVID-19 infection. In approximately 14% of the patients affected by the novel coronavirus, the infection progresses with the development of pneumonia that requires mechanical ventilation. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. In our opinion, mesenchymal stem cell secretome could offer a new therapeutic approach in treating COVID-19 pneumonia, due to the broad pharmacological effects it shows, including anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties. View Full-Text
Keywords: SARS-CoV-2; COVID-19; acute respiratory distress syndrome; mesenchymal stem cells; extracellular vesicles; microvesicles; exosomes; secretome SARS-CoV-2; COVID-19; acute respiratory distress syndrome; mesenchymal stem cells; extracellular vesicles; microvesicles; exosomes; secretome
MDPI and ACS Style

Bari, E.; Ferrarotti, I.; Saracino, L.; Perteghella, S.; Torre, M.L.; Corsico, A.G. Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use. Cells 2020, 9, 924. https://doi.org/10.3390/cells9040924

AMA Style

Bari E, Ferrarotti I, Saracino L, Perteghella S, Torre ML, Corsico AG. Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use. Cells. 2020; 9(4):924. https://doi.org/10.3390/cells9040924

Chicago/Turabian Style

Bari, Elia, Ilaria Ferrarotti, Laura Saracino, Sara Perteghella, Maria L. Torre, and Angelo G. Corsico 2020. "Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use" Cells 9, no. 4: 924. https://doi.org/10.3390/cells9040924

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