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Human γδ TCR Repertoires in Health and Disease

1
Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
2
Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Cells 2020, 9(4), 800; https://doi.org/10.3390/cells9040800
Received: 28 February 2020 / Revised: 19 March 2020 / Accepted: 23 March 2020 / Published: 26 March 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2+ and Vδ1+ T cells. Of those two subsets, Vδ2+ T cells seem to better fit into a role of innate T cells with semi-invariant TCR usage, as compared to an adaptive-like biology of some Vδ1+ subsets. Yet, this distinction into innate-like Vδ2+ and adaptive-like Vδ1+ γδ T cells does not quite recapitulate the full diversity of γδ T cell subsets, ligands and interaction modes. Here, we review how the recent introduction of high-throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire diversity beyond Vδ2+ and Vδ1+ T cells. We discuss the current understanding of clonal composition and the dynamics of human γδ TCR repertoires in health and disease. View Full-Text
Keywords: γδ T cells; γδ TCR repertoires; TCR diversity; innate T cells γδ T cells; γδ TCR repertoires; TCR diversity; innate T cells
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MDPI and ACS Style

Fichtner, A.S.; Ravens, S.; Prinz, I. Human γδ TCR Repertoires in Health and Disease. Cells 2020, 9, 800.

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