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Human γδ TCR Repertoires in Health and Disease

Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625 Hannover, Germany
Author to whom correspondence should be addressed.
Cells 2020, 9(4), 800;
Received: 28 February 2020 / Revised: 19 March 2020 / Accepted: 23 March 2020 / Published: 26 March 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2+ and Vδ1+ T cells. Of those two subsets, Vδ2+ T cells seem to better fit into a role of innate T cells with semi-invariant TCR usage, as compared to an adaptive-like biology of some Vδ1+ subsets. Yet, this distinction into innate-like Vδ2+ and adaptive-like Vδ1+ γδ T cells does not quite recapitulate the full diversity of γδ T cell subsets, ligands and interaction modes. Here, we review how the recent introduction of high-throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire diversity beyond Vδ2+ and Vδ1+ T cells. We discuss the current understanding of clonal composition and the dynamics of human γδ TCR repertoires in health and disease. View Full-Text
Keywords: γδ T cells; γδ TCR repertoires; TCR diversity; innate T cells γδ T cells; γδ TCR repertoires; TCR diversity; innate T cells
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Fichtner, A.S.; Ravens, S.; Prinz, I. Human γδ TCR Repertoires in Health and Disease. Cells 2020, 9, 800.

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