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Review

HSP70 Multi-Functionality in Cancer

1
Department of Biology, Lomonosov Moscow State University, 119192 Moscow, Russia
2
Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 587; https://doi.org/10.3390/cells9030587
Received: 30 January 2020 / Revised: 20 February 2020 / Accepted: 28 February 2020 / Published: 2 March 2020
(This article belongs to the Special Issue Molecular Chaperones: Cancer and Cell Death)
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer “addiction” to HSP70, tightly linking tumor survival and growth to the HSP70 expression. HSP70 operates in different states through its catalytic cycle, suggesting that it can multi-function in malignant cells in any of these states. Clinically, tumor cells intensively release HSP70 in extracellular microenvironment, resulting in diverse outcomes for patient survival. Given its clinical significance, small molecule inhibitors were developed to target different sites of the HSP70 machinery. Furthermore, several HSP70-based immunotherapy approaches were assessed in clinical trials. This review will explore different roles of HSP70 on cancer progression and emphasize the importance of understanding the flexibility of HSP70 nature for future development of anti-cancer therapies. View Full-Text
Keywords: HSP70; cancer; immunotherapy; apoptosis; authophagy; senescence; metastasis; exosomes HSP70; cancer; immunotherapy; apoptosis; authophagy; senescence; metastasis; exosomes
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MDPI and ACS Style

Albakova, Z.; Armeev, G.A.; Kanevskiy, L.M.; Kovalenko, E.I.; Sapozhnikov, A.M. HSP70 Multi-Functionality in Cancer. Cells 2020, 9, 587. https://doi.org/10.3390/cells9030587

AMA Style

Albakova Z, Armeev GA, Kanevskiy LM, Kovalenko EI, Sapozhnikov AM. HSP70 Multi-Functionality in Cancer. Cells. 2020; 9(3):587. https://doi.org/10.3390/cells9030587

Chicago/Turabian Style

Albakova, Zarema, Grigoriy A. Armeev, Leonid M. Kanevskiy, Elena I. Kovalenko, and Alexander M. Sapozhnikov 2020. "HSP70 Multi-Functionality in Cancer" Cells 9, no. 3: 587. https://doi.org/10.3390/cells9030587

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