Next Article in Journal
Cardioprotective Potential of Human Endothelial-Colony Forming Cells from Diabetic and Nondiabetic Donors
Next Article in Special Issue
Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells
Previous Article in Journal
The Potential of Computational Modeling to Predict Disease Course and Treatment Response in Patients with Relapsing Multiple Sclerosis
Previous Article in Special Issue
At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer

HSP70 Multi-Functionality in Cancer

Department of Biology, Lomonosov Moscow State University, 119192 Moscow, Russia
Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 587;
Received: 30 January 2020 / Revised: 20 February 2020 / Accepted: 28 February 2020 / Published: 2 March 2020
(This article belongs to the Special Issue Molecular Chaperones: Cancer and Cell Death)
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer “addiction” to HSP70, tightly linking tumor survival and growth to the HSP70 expression. HSP70 operates in different states through its catalytic cycle, suggesting that it can multi-function in malignant cells in any of these states. Clinically, tumor cells intensively release HSP70 in extracellular microenvironment, resulting in diverse outcomes for patient survival. Given its clinical significance, small molecule inhibitors were developed to target different sites of the HSP70 machinery. Furthermore, several HSP70-based immunotherapy approaches were assessed in clinical trials. This review will explore different roles of HSP70 on cancer progression and emphasize the importance of understanding the flexibility of HSP70 nature for future development of anti-cancer therapies. View Full-Text
Keywords: HSP70; cancer; immunotherapy; apoptosis; authophagy; senescence; metastasis; exosomes HSP70; cancer; immunotherapy; apoptosis; authophagy; senescence; metastasis; exosomes
Show Figures

Figure 1

MDPI and ACS Style

Albakova, Z.; Armeev, G.A.; Kanevskiy, L.M.; Kovalenko, E.I.; Sapozhnikov, A.M. HSP70 Multi-Functionality in Cancer. Cells 2020, 9, 587.

AMA Style

Albakova Z, Armeev GA, Kanevskiy LM, Kovalenko EI, Sapozhnikov AM. HSP70 Multi-Functionality in Cancer. Cells. 2020; 9(3):587.

Chicago/Turabian Style

Albakova, Zarema, Grigoriy A. Armeev, Leonid M. Kanevskiy, Elena I. Kovalenko, and Alexander M. Sapozhnikov 2020. "HSP70 Multi-Functionality in Cancer" Cells 9, no. 3: 587.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop