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Review

Job Opening for Nucleosome Mechanic: Flexibility Required

by 1,2,†, 2,† and 2,*
1
Department of Chemistry and Biochemistry, Institute for Physical Science and Technology, University of Maryland, College Park, MD 20740, USA
2
Chromatin Structure and Epigenetic Mechanisms, Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Cells 2020, 9(3), 580; https://doi.org/10.3390/cells9030580
Received: 11 February 2020 / Revised: 25 February 2020 / Accepted: 26 February 2020 / Published: 1 March 2020
(This article belongs to the Special Issue Histone Variants from Structure to Molecular Function)
The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical properties. In recent years, innovative work deploying interdisciplinary approaches including computational modeling, in vitro manipulations of purified and native chromatin have resulted in deep mechanistic insights into how the mechanics of chromatin might contribute to its function. The picture that emerges is one of a nucleus that is shaped as much by external forces pressing down upon it, as internal forces pushing outwards from the chromatin. These properties may have evolved to afford the cell a dynamic and reversible force-induced communication highway which allows rapid coordination between external cues and internal genomic function. View Full-Text
Keywords: chromatin; mechanics; nucleosomes; dynamics; epigenetics chromatin; mechanics; nucleosomes; dynamics; epigenetics
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MDPI and ACS Style

Pitman, M.; Melters, D.P.; Dalal, Y. Job Opening for Nucleosome Mechanic: Flexibility Required. Cells 2020, 9, 580. https://doi.org/10.3390/cells9030580

AMA Style

Pitman M, Melters DP, Dalal Y. Job Opening for Nucleosome Mechanic: Flexibility Required. Cells. 2020; 9(3):580. https://doi.org/10.3390/cells9030580

Chicago/Turabian Style

Pitman, Mary, Daniël P. Melters, and Yamini Dalal. 2020. "Job Opening for Nucleosome Mechanic: Flexibility Required" Cells 9, no. 3: 580. https://doi.org/10.3390/cells9030580

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