Next Article in Journal
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma
Previous Article in Journal
Impact of JNK and Its Substrates on Dendritic Spine Morphology
Previous Article in Special Issue
Priority Strategy of Intracellular Ca2+ Homeostasis in Skeletal Muscle Fibers during the Multiple Stresses of Hibernation
Open AccessReview

Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy

Stem Cell Laboratory, Department of Pathophysiology and Transplantation, University of Milan, Unit of Neurology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Dino Ferrari Center, 20122 Milan, Italy
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(2), 441; https://doi.org/10.3390/cells9020441 (registering DOI)
Received: 20 January 2020 / Revised: 11 February 2020 / Accepted: 11 February 2020 / Published: 14 February 2020
The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2). IGF2/IGF2R interaction influences cell growth, survival, and migration in normal tissue development, and the deregulation of IGF2R expression has been associated with growth-related disease and cancer. IGF2R overexpression has been implicated in heart and muscle disease progression. Recent research findings suggest novel approaches to target IGF2R action. This review highlights recent advances in the understanding of the IGF2R structure and pathways related to muscle homeostasis.
Keywords: IGF2R; muscle homeostasis; inflammation; muscular dystrophy; pericytes IGF2R; muscle homeostasis; inflammation; muscular dystrophy; pericytes
MDPI and ACS Style

Torrente, Y.; Bella, P.; Tripodi, L.; Villa, C.; Farini, A. Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy. Cells 2020, 9, 441.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop