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Open AccessFeature PaperArticle

A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo

1
Research Unit Bioactive Natural Products and Biotechnology UR17ES49, Faculty of Dental Medicine of Monastir, University of Monastir, Avicenne street, 5000 Monastir, Tunisia
2
Université de Bourgogne Franche-Comté, F-21000 Dijon, France
3
INSERM Research Center U1231 – Cancer and Adaptive Immune Response Team, F-21000 Dijon, France
4
Centre anticancéreux Georges François Leclerc Center, F-21000 Dijon, France
*
Authors to whom correspondence should be addressed.
Two senior authors contributed equally of this work.
Cells 2020, 9(2), 362; https://doi.org/10.3390/cells9020362
Received: 30 December 2019 / Revised: 24 January 2020 / Accepted: 28 January 2020 / Published: 4 February 2020
Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially for some anticancer drugs such as cisplatin, which induces a nephrotoxicity. In the strategy of research for active molecules capable both of exerting a protective action against the deleterious effects of cisplatin and exerting a chemosensitizing action with regard to cancer cells, we tested the potential effects of Ephedra alata Decne extract (E.A.) rich in polyphenolic compounds towards a 4T1 breast cancer model in vitro and in vivo. We showed that E.A. extract inhibited cell viability of 4T1 breast cancer cells and induced apoptosis in a caspase-dependent manner, which involved intrinsic pathways. Very interestingly, we observed a synergic antiproliferative and pro-apoptotic action with cisplatin. These events were associated with a strong decrease of breast tumor growth in mice treated with an E.A./cisplatin combination and simultaneously with a decrease of hepato- and nephrotoxicities of cisplatin.
Keywords: Ephedra; cisplatin; polyphenols; breast cancer; chemosensibilisation Ephedra; cisplatin; polyphenols; breast cancer; chemosensibilisation
MDPI and ACS Style

Sioud, F.; Amor, S.; Toumia, I.; Lahmar, A.; Aires, V.; Chekir-Ghedira, L.; Delmas, D. A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo. Cells 2020, 9, 362.

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