Next Article in Journal
Tendon Biomimetic Electrospun PLGA Fleeces Induce an Early Epithelial-Mesenchymal Transition and Tenogenic Differentiation on Amniotic Epithelial Stem Cells
Next Article in Special Issue
Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages
Previous Article in Journal
Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices
Previous Article in Special Issue
Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer
Article

Opposite Macrophage Polarization in Different Subsets of Ovarian Cancer: Observation from a Pilot Study

1
ImmunOvar Research Group, Laboratory of Tumor Immunology and Immunotherapy, Department of Oncology, KU Leuven, 3000 Leuven, Belgium
2
Oncoinvent AS, 0484 Oslo, Norway
3
PARCC, HEGP Institute (team 9), INSERM U970, Université Paris Descartes, 75006 Paris, France
4
Vascular Patterning Lab, Center for Cancer Biology, VIB, KU Leuven, 3000 Leuven, Belgium
5
Department of Gynecology and Gynecologic Oncology, Kliniken Essen Mitte (KEM), 45136 Essen, Germany
6
Department of Gynecology and Obstetrics, Leuven Cancer Institute, University Hospitals Leuven (UZ Leuven), 3000 Leuven, Belgium
7
Laboratory of Gynecologic Oncology, Department of Oncology, KU, Leuven, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Cells 2020, 9(2), 305; https://doi.org/10.3390/cells9020305
Received: 22 November 2019 / Revised: 13 January 2020 / Accepted: 23 January 2020 / Published: 27 January 2020
The role of the innate immune system in ovarian cancer is gaining importance. The relevance of tumor-associated macrophages (TAM) is insufficiently understood. In this pilot project, comprising the immunofluorescent staining of 30 biopsies taken from 24 patients with ovarian cancer, we evaluated the presence of total TAM (cluster of differentiation (CD) 68 expression), M1 (major histocompatibility complex (MHC) II expression), and M2 (anti-mannose receptor C type 1 (MRC1) expression), and the blood vessel diameter. We observed a high M1/M2 ratio in low-grade ovarian cancer compared to high-grade tumors, more total TAM and M2 in metastatic biopsies, and a further increase in total TAM and M2 at interval debulking, without beneficial effects of bevacizumab. The blood vessel diameter was indicative for M2 tumor infiltration (Spearman correlation coefficient of 0.65). These data mainly reveal an immune beneficial environment in low-grade ovarian cancer in contrast to high-grade serous ovarian cancer, where immune suppression is not altered by neoadjuvant therapy. View Full-Text
Keywords: ovarian cancer; macrophages; M2 ovarian cancer; macrophages; M2
Show Figures

Figure 1

MDPI and ACS Style

Vankerckhoven, A.; Wouters, R.; Mathivet, T.; Ceusters, J.; Baert, T.; Van Hoylandt, A.; Gerhardt, H.; Vergote, I.; Coosemans, A. Opposite Macrophage Polarization in Different Subsets of Ovarian Cancer: Observation from a Pilot Study. Cells 2020, 9, 305. https://doi.org/10.3390/cells9020305

AMA Style

Vankerckhoven A, Wouters R, Mathivet T, Ceusters J, Baert T, Van Hoylandt A, Gerhardt H, Vergote I, Coosemans A. Opposite Macrophage Polarization in Different Subsets of Ovarian Cancer: Observation from a Pilot Study. Cells. 2020; 9(2):305. https://doi.org/10.3390/cells9020305

Chicago/Turabian Style

Vankerckhoven, Ann, Roxanne Wouters, Thomas Mathivet, Jolien Ceusters, Thaïs Baert, Anaïs Van Hoylandt, Holger Gerhardt, Ignace Vergote, and An Coosemans. 2020. "Opposite Macrophage Polarization in Different Subsets of Ovarian Cancer: Observation from a Pilot Study" Cells 9, no. 2: 305. https://doi.org/10.3390/cells9020305

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop