Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons
1
Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
2
Department of Life Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
3
Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
5
Department of Medical Research, Kaohsiung Medical University Hostpital, Kaohsiung 80708, Taiwan
6
Department of Anatomy, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Medical Education, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
8
Akouos, Inc., Boston, MA 02210, USA
9
Department of Neurology, National Taiwan University Hospital, Taipei 10002, Taiwan
10
Graduate Institute of Brian and Mind Sciences, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
11
Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10055, Taiwan
*
Author to whom correspondence should be addressed.
Cells 2020, 9(12), 2725; https://doi.org/10.3390/cells9122725
Received: 14 October 2020
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Accepted: 16 December 2020
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Published: 21 December 2020
(This article belongs to the Special Issue Molecular and Neurobiological Basis of Pain Sensation Involved in Fibromyalgia and Peripheral Neuropathy)
Neuropathic pain exerts a global burden caused by the lesions in the somatosensory nerve system, including the central and peripheral nervous systems. The mechanisms of nerve injury-induced neuropathic pain involve multiple mechanisms, various signaling pathways, and molecules. Currently, poor efficacy is the major limitation of medications for treating neuropathic pain. Thus, understanding the detailed molecular mechanisms should shed light on the development of new therapeutic strategies for neuropathic pain. Several well-established in vivo pain models were used to investigate the detail mechanisms of peripheral neuropathic pain. Molecular mediators of pain are regulated differentially in various forms of neuropathic pain models; these regulators include purinergic receptors, transient receptor potential receptor channels, and voltage-gated sodium and calcium channels. Meanwhile, post-translational modification and transcriptional regulation are also altered in these pain models and have been reported to mediate several pain related molecules. In this review, we focus on molecular mechanisms and mediators of neuropathic pain with their corresponding transcriptional regulation and post-translational modification underlying peripheral sensitization in the dorsal root ganglia. Taken together, these molecular mediators and their modification and regulations provide excellent targets for neuropathic pain treatment.
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Keywords:
neuropathic pain; peripheral sensitization; dorsal root ganglia; transcriptional regulation; post-translational modification
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MDPI and ACS Style
Yeh, T.-Y.; Luo, I.-W.; Hsieh, Y.-L.; Tseng, T.-J.; Chiang, H.; Hsieh, S.-T. Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons. Cells 2020, 9, 2725. https://doi.org/10.3390/cells9122725
AMA Style
Yeh T-Y, Luo I-W, Hsieh Y-L, Tseng T-J, Chiang H, Hsieh S-T. Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons. Cells. 2020; 9(12):2725. https://doi.org/10.3390/cells9122725
Chicago/Turabian StyleYeh, Ti-Yen, I-Wei Luo, Yu-Lin Hsieh, To-Jung Tseng, Hao Chiang, and Sung-Tsang Hsieh. 2020. "Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons" Cells 9, no. 12: 2725. https://doi.org/10.3390/cells9122725
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