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TRPM Channels in Human Diseases

Faculty of Life Science, Universidad Andrés Bello, Santiago 8370186, Chile
Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Universidad de Chile, Santiago 8380453, Chile
Faculty of Medicine, School of Chemistry and Pharmacy, Universidad Andrés Bello, Santiago 8370186, Chile
Vancouver Prostate Centre, Vancouver, BC V6Z 1Y6, Canada
Department of Urological Sciences, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago 7560484, Chile
Millennium Institute on Immunology and Immunotherapy, Santiago 8370146, Chile
Program of Cellular and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(12), 2604;
Received: 4 November 2020 / Revised: 30 November 2020 / Accepted: 1 December 2020 / Published: 4 December 2020
(This article belongs to the Special Issue MiNICAD Special Issue: Ion Channels and Human Diseases)
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM subfamily and their functions. The TRPM subfamily is composed of eight members consisting of four six-transmembrane domain subunits, resulting in homomeric or heteromeric channels. From a structural point of view, based on the homology sequence of the coiled-coil in the C-terminus, the eight TRPM members are clustered into four groups: TRPM1/M3, M2/M8, M4/M5 and M6/M7. TRPM subfamily members have been involved in several physiological functions. However, they are also linked to diverse pathophysiological human processes. Alterations in the expression and function of TRPM subfamily ion channels might generate several human diseases including cardiovascular and neurodegenerative alterations, organ dysfunction, cancer and many other channelopathies. These effects position them as remarkable putative targets for novel diagnostic strategies, drug design and therapeutic approaches. Here, we review the current knowledge about the main characteristics of all members of the TRPM family, focusing on their actions in human diseases. View Full-Text
Keywords: TRPM channels; human diseases; ion channels TRPM channels; human diseases; ion channels
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MDPI and ACS Style

Jimenez, I.; Prado, Y.; Marchant, F.; Otero, C.; Eltit, F.; Cabello-Verrugio, C.; Cerda, O.; Simon, F. TRPM Channels in Human Diseases. Cells 2020, 9, 2604.

AMA Style

Jimenez I, Prado Y, Marchant F, Otero C, Eltit F, Cabello-Verrugio C, Cerda O, Simon F. TRPM Channels in Human Diseases. Cells. 2020; 9(12):2604.

Chicago/Turabian Style

Jimenez, Ivanka; Prado, Yolanda; Marchant, Felipe; Otero, Carolina; Eltit, Felipe; Cabello-Verrugio, Claudio; Cerda, Oscar; Simon, Felipe. 2020. "TRPM Channels in Human Diseases" Cells 9, no. 12: 2604.

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