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Open AccessFeature PaperReview

Expression and Signaling of β-Adrenoceptor Subtypes in the Diabetic Heart

1
Department of Pharmacology, Faculty of Pharmacy, Ankara University, 06560 Ankara, Turkey
2
Department of Pharmacology, Faculty of Pharmacy, Izmir Katip Celebi University, 35620 Izmir, Turkey
3
Department of Pharmacology, Johannes Gutenberg University, 55131 Mainz, Germany
*
Author to whom correspondence should be addressed.
Cells 2020, 9(12), 2548; https://doi.org/10.3390/cells9122548
Received: 28 October 2020 / Revised: 20 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020
(This article belongs to the Special Issue Advances in Adrenergic Receptor Biology)
Diabetes is a chronic, endocrine disorder that effects millions of people worldwide. Cardiovascular complications are the major cause of diabetes-related morbidity and mortality. Cardiac β1- and β2-adrenoceptor (AR) stimulation mediates positive inotropy and chronotropy, whereas β3-AR mediates negative inotropic effect. Changes in β-AR responsiveness are thought to be an important factor that contributes to the diabetic cardiac dysfunction. Diabetes related changes in β-AR expression, signaling, and β-AR mediated cardiac function have been studied by several investigators for many years. In the present review, we have screened PubMed database to obtain relevant articles on this topic. Our search has ended up with wide range of different findings about the effect of diabetes on β-AR mediated changes both in molecular and functional level. Considering these inconsistent findings, the effect of diabetes on cardiac β-AR still remains to be clarified. View Full-Text
Keywords: diabetes; heart; beta adrenoceptor diabetes; heart; beta adrenoceptor
MDPI and ACS Style

Erdogan, B.R.; Michel, M.C.; Arioglu-Inan, E. Expression and Signaling of β-Adrenoceptor Subtypes in the Diabetic Heart. Cells 2020, 9, 2548. https://doi.org/10.3390/cells9122548

AMA Style

Erdogan BR, Michel MC, Arioglu-Inan E. Expression and Signaling of β-Adrenoceptor Subtypes in the Diabetic Heart. Cells. 2020; 9(12):2548. https://doi.org/10.3390/cells9122548

Chicago/Turabian Style

Erdogan, Betul R.; Michel, Martin C.; Arioglu-Inan, Ebru. 2020. "Expression and Signaling of β-Adrenoceptor Subtypes in the Diabetic Heart" Cells 9, no. 12: 2548. https://doi.org/10.3390/cells9122548

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